Protein kinase inhibitor 5

Name: Protein kinase inhibitor 5
Brand: TargetMol
SKU: T79125
Rating: 4.5 (1 reviews)

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Catalog No. T79125Cas No. 2278204-94-5

Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, with an IC50 of 1.8 nM, and effectively suppresses cell viability [1].

Protein kinase inhibitor 5

😃Good

Catalog No. T79125Cas No. 2278204-94-5

Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, with an IC50 of 1.8 nM, and effectively suppresses cell viability [1].

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, with an IC50 of 1.8 nM, and effectively suppresses cell viability [1].
Targets&IC50	TrkA:1.8 nM
In vitro	Protein kinase inhibitor 5, at concentrations ranging from 0.014 to 10 µM over a 72-hour period, exhibits a GI50 value of less than 1 nM against TEL-NTRK1-BaF3 cells [1].

Chemical Properties

Molecular Weight	531.6
Formula	C₂₉H₃₁F₂N₇O
Cas No.	2278204-94-5
Smiles	FC1=C([C@@H]2N(CCC2)C3=NC4=C(NC(=O)C5=CC=C(CN6CCN(C)CC6)C=C5)C=NN4C=C3)C=C(F)C=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc