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L-Phenylalanine

Name: L-Phenylalanine
Brand: TargetMol
SKU: T3377
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3377Cas No. 63-91-2

Alias phenylalanine, 3-Phenyl-L-alanine, (S)-2-Amino-3-phenylpropionic acid

L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.

L-Phenylalanine

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Purity: 99.87%

Catalog No. T3377Alias phenylalanine, 3-Phenyl-L-alanine, (S)-2-Amino-3-phenylpropionic acidCas No. 63-91-2

L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$31	-	In Stock
10 g	$45	-	In Stock
25 g	$72	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Color:White

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Product Introduction

L-Phenylalanine AI Summary

L-Phenylalanine exhibits a range of bioactivities, primarily demonstrating significant potential in modulating the solubility and function of various hemoglobin variants and carbonic anhydrase (CA) isoenzymes. The compound enhances the solubility ratios of Haemoglobin S (HbS) and Deoxyhemoglobin S (dHbS) over control conditions at increasing concentrations, suggesting potential antisickling and antigelling properties. It exhibits substantial activation of several human recombinant CA isoforms, including CA1, CA2, CA5A, CA5B, and others, with varying activation constants (KA) and catalytic efficiencies (Kcat), indicating a robust role in CA enzyme modulation. Furthermore, L-Phenylalanine interacts with the LAT1 transporter, inhibiting leucine uptake with a Ki value of 55,000 nM, and acts as an inhibitor of intestinal and tissue-nonspecific alkaline phosphatases with IC50 values around 80,210 nM and higher. Additionally, it has been shown to have a positive permeability profile across rat intestinal membranes, a low partition coefficient (LogP), and reasonable bioavailability, highlighting its potential as a multifunctional therapeutic agent. However, it may also exhibit some cytotoxic effects and influence lifespan negatively in specific models like Caenorhabditis elegans. Overall, L-Phenylalanine demonstrates diverse pharmacological properties with significant implications for therapeutic use in treating hemoglobinopathies and modulating enzyme activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.
Targets&IC50	α2δ Ca2+ channel:980 nM(ki)
Synonyms	phenylalanine, 3-Phenyl-L-alanine, (S)-2-Amino-3-phenylpropionic acid

Chemical Properties

Molecular Weight	165.19
Formula	C₉H₁₁NO₂
Cas No.	63-91-2
Smiles	C([C@@H](C(O)=O)N)C1=CC=CC=C1
Relative Density.	1.343 g/cm3. Temperature:20 °C.;1.343. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: insoluble

H2O: 12.5 mg/mL (75.67 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	6.0536 mL	30.2682 mL	60.5364 mL	302.6818 mL
5 mM	1.2107 mL	6.0536 mL	12.1073 mL	60.5364 mL
10 mM	0.6054 mL	3.0268 mL	6.0536 mL	30.2682 mL
20 mM	0.3027 mL	1.5134 mL	3.0268 mL	15.1341 mL
50 mM	0.1211 mL	0.6054 mL	1.2107 mL	6.0536 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc