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Ginsenoside Rb2

Name: Ginsenoside Rb2
Brand: TargetMol
SKU: T3919
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3919Cas No. 11021-13-9

Alias Ginsenoside C

Ginsenoside Rb2 (Ginsenoside C) found in species of Panax, upregulating GPR120 gene expression.

Ginsenoside Rb2

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Purity: 99.93%

Catalog No. T3919Alias Ginsenoside CCas No. 11021-13-9

Ginsenoside Rb2 (Ginsenoside C) found in species of Panax, upregulating GPR120 gene expression.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$31	In Stock	In Stock
5 mg	$46	In Stock	In Stock
10 mg	$63	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$147	In Stock	In Stock
100 mg	$215	In Stock	In Stock
200 mg	$318	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.93%

Color:White

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COA HNMR LCMS

Product Introduction

Ginsenoside Rb2 AI Summary

Ginsenoside Rb2 exhibits promising medicinal properties across various biological activities, suggesting potential applications in several therapeutic areas. In streptozotocin-induced diabetic Wistar rats, it shows significant antidiabetic activity by increasing serum protein and albumin levels, decreasing serum glucose levels, and enhancing the incorporation of [14C]leucine into various hepatic fractions. Additionally, it affects nitrogen balance by modifying measures of residual urinary and fecal nitrogen, and absorbed and retained nitrogen, in diabetic rats. In mouse hepatocytes, Ginsenoside Rb2 demonstrates substantial hepatoprotective activity by improving cell survival rates and significantly inhibiting D-galactosamine/TNFalpha-induced cell death, with efficacy ranging from 7.6% to 43.3% at different concentrations and an IC50 value of 105,000.0 nM. The compound also shows potent anti-proliferative effects in human U251 cells and rat C6 cells, significantly suppressing cell viability at a 100 µM concentration after 72 hours, with inhibition rates of 77.45% and 80.92%, respectively. Moreover, Ginsenoside Rb2 activates the human SIRT1 enzyme at concentrations ranging from 1 to 50 µM, achieving an activity level of 8.0% compared to the control, as assessed by a fluorescence assay. It also demonstrates a strong activation of the AMPKalpha2beta1gamma1 complex in the presence of CaMKKbeta, resulting in a 4.7-fold increase in activity and an EC50 of 16.8 nM. Collectively, these bioactivities establish Ginsenoside Rb2 as a versatile candidate with multiple therapeutic potentials, including anti-diabetic, hepatoprotective, anti-proliferative, and enzyme-activating properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ginsenoside Rb2 (Ginsenoside C) found in species of Panax, upregulating GPR120 gene expression.
Synonyms	Ginsenoside C

Chemical Properties

Molecular Weight	1079.27
Formula	C₅₃H₉₀O₂₂
Cas No.	11021-13-9
Smiles	CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2OC[C@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C
Relative Density.	1.42 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL（insoluble）

DMSO: 100 mg/mL (92.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (4.63 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9266 mL	4.6328 mL	9.2655 mL	46.3276 mL
5 mM	0.1853 mL	0.9266 mL	1.8531 mL	9.2655 mL
10 mM	0.0927 mL	0.4633 mL	0.9266 mL	4.6328 mL
20 mM	0.0463 mL	0.2316 mL	0.4633 mL	2.3164 mL
50 mM	0.0185 mL	0.0927 mL	0.1853 mL	0.9266 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc