Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody

😃Good
Catalog No. TMAC-04122

Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TrkA (Tyr701). Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody can be used in WB,IHC.

Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody

Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody

😃Good
Catalog No. TMAC-04122
Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TrkA (Tyr701). Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody can be used in WB,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2177-10 days
100 μL$3177-10 days
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View More

Product Introduction

Bioactivity
Description
Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TrkA (Tyr701). Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody can be used in WB,IHC.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-3000; IHC: 1:50-100
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundReceptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of tyrosine 701 (I-L-Y(p)-R-K) derived from Human Trk A
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 87 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody | purchase Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody | Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody cost | order Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody | Anti-Phospho-TrkA (Tyr701) Polyclonal Antibody molecular weight