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Anti-MELK Antibody (8J637)
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Catalog No. TMAB-08748
Anti-MELK Antibody (8J637) is a Rabbit antibody targeting MELK. Anti-MELK Antibody (8J637) can be used in WB.
Anti-MELK Antibody (8J637)
Anti-MELK Antibody (8J637)
Copy Product Info😃Good
Catalog No. TMAB-08748
Anti-MELK Antibody (8J637) is a Rabbit antibody targeting MELK. Anti-MELK Antibody (8J637) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-MELK Antibody (8J637) is a Rabbit antibody targeting MELK. Anti-MELK Antibody (8J637) can be used in WB. |
| Ig Type | IgG |
| Clone | 8J637 |
| Reactivity | Human |
| Verified Activity | 25 μg total protein per lane of various lysates (see on figure) probed with MELK monoclonal antibody, unconjugated (TMAB-08748) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Expressed in placenta, kidney, thymus, testis, ovary and intestine. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. |
| Immunogen | A synthesized peptide: human MELK |
| Antigen Species | Human |
| Gene Name | MELK |
| Gene ID | |
| Protein Name | Maternal embryonic leucine zipper kinase |
| Uniprot ID | |
| Function | Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis. |
| Molecular Weight | Theoretical: 75 kDa. Actual: 75 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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