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Dactinomycin

😃Good
Catalog No. TN9827Cas No. 50-76-0
Alias Dactinomycin D, Actinomycin IV

Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator produced by Streptomyces bacteria fermentation, which inhibits transcription and replication by inserting into the DNA double helix, and can also promote p53 phosphorylation and accumulation through MDM2 overexpression, serving as a chemotherapy drug for cancer treatment.

Dactinomycin

Dactinomycin

😃Good
Purity: 99.70%
Catalog No. TN9827Alias Dactinomycin D, Actinomycin IVCas No. 50-76-0
Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator produced by Streptomyces bacteria fermentation, which inhibits transcription and replication by inserting into the DNA double helix, and can also promote p53 phosphorylation and accumulation through MDM2 overexpression, serving as a chemotherapy drug for cancer treatment.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30In StockIn Stock
5 mg$58In StockIn Stock
10 mg$105In StockIn Stock
25 mg$224In StockIn Stock
50 mg$380In StockIn Stock
100 mg$598-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.70%
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Product Introduction

Bioactivity
Description
Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator produced by Streptomyces bacteria fermentation, which inhibits transcription and replication by inserting into the DNA double helix, and can also promote p53 phosphorylation and accumulation through MDM2 overexpression, serving as a chemotherapy drug for cancer treatment.
In vitro
Method:
Cell viability was assessed by treating pancreatic cancer cells (PANC-1) with Dactinomycin at concentrations of 1–100 ng/mL for 24–96 hours.

Result:
Dactinomycin induced apoptosis and inhibited the growth of PANC-1 cells.[4]
In vivo
Method:
In a mouse model of chronic lymphocytic leukemia, Dactinomycin was administered intraperitoneally at a dose of 0.06 mg/kg for 14 consecutive days.

Result:
Dactinomycin prolonged the survival time of mice with chronic lymphocytic leukemia. [6]
SynonymsDactinomycin D, Actinomycin IV
Chemical Properties
Molecular Weight1255.42
FormulaC62H86N12O16
Cas No.50-76-0
SmilesC(N[C@@H]1C(=O)N[C@H](C(C)C)C(=O)N2[C@@](CCC2)(C(=O)N(C)CC(=O)N(C)[C@@H]([C@@H](C)C)C(=O)O[C@@H]1C)[H])(=O)C=3C=4C(OC=5C(N4)=C(C(N[C@@H]6C(=O)N[C@H](C(C)C)C(=O)N7[C@@](CCC7)(C(=O)N(C)CC(=O)N(C)[C@@H]([C@H](C)C)C(=O)O[C@@H]6C)[H])=O)C=CC5C)=C(C)C(=O)C3N
ColorRed
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (63.72 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (2.63 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.7965 mL3.9827 mL7.9655 mL39.8273 mL
5 mM0.1593 mL0.7965 mL1.5931 mL7.9655 mL
10 mM0.0797 mL0.3983 mL0.7965 mL3.9827 mL
20 mM0.0398 mL0.1991 mL0.3983 mL1.9914 mL
50 mM0.0159 mL0.0797 mL0.1593 mL0.7965 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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