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Dactinomycin
🥰Excellent
Catalog No. TN9827Cas No. 50-76-0
Alias Dactinomycin D, Actinomycin IV
Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator produced by Streptomyces bacteria fermentation, which inhibits transcription and replication by inserting into the DNA double helix, and can also promote p53 phosphorylation and accumulation through MDM2 overexpression, serving as a chemotherapy drug for cancer treatment.
Dactinomycin
🥰Excellent
Purity: 99.70%
Catalog No. TN9827Alias Dactinomycin D, Actinomycin IVCas No. 50-76-0
Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator produced by Streptomyces bacteria fermentation, which inhibits transcription and replication by inserting into the DNA double helix, and can also promote p53 phosphorylation and accumulation through MDM2 overexpression, serving as a chemotherapy drug for cancer treatment.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $58 | In Stock | |
| 10 mg | $105 | In Stock | |
| 25 mg | $224 | In Stock | |
| 50 mg | $380 | In Stock | |
| 100 mg | $598 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.70%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Dactinomycin D (Actinomycin IV) is an antibiotic and autophagy activator produced by Streptomyces bacteria fermentation, which inhibits transcription and replication by inserting into the DNA double helix, and can also promote p53 phosphorylation and accumulation through MDM2 overexpression, serving as a chemotherapy drug for cancer treatment. |
| In vitro | Method: Cell viability was assessed by treating pancreatic cancer cells (PANC-1) with Dactinomycin at concentrations of 1–100 ng/mL for 24–96 hours. Result: Dactinomycin induced apoptosis and inhibited the growth of PANC-1 cells.[4] |
| In vivo | Method: In a mouse model of chronic lymphocytic leukemia, Dactinomycin was administered intraperitoneally at a dose of 0.06 mg/kg for 14 consecutive days. Result: Dactinomycin prolonged the survival time of mice with chronic lymphocytic leukemia. [6] |
| Synonyms | Dactinomycin D, Actinomycin IV |
| Molecular Weight | 1255.42 |
| Formula | C62H86N12O16 |
| Cas No. | 50-76-0 |
| Smiles | C(N[C@@H]1C(=O)N[C@H](C(C)C)C(=O)N2[C@@](CCC2)(C(=O)N(C)CC(=O)N(C)[C@@H]([C@@H](C)C)C(=O)O[C@@H]1C)[H])(=O)C=3C=4C(OC=5C(N4)=C(C(N[C@@H]6C(=O)N[C@H](C(C)C)C(=O)N7[C@@](CCC7)(C(=O)N(C)CC(=O)N(C)[C@@H]([C@H](C)C)C(=O)O[C@@H]6C)[H])=O)C=CC5C)=C(C)C(=O)C3N |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (63.72 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: buy Dactinomycin | purchase Dactinomycin | Dactinomycin cost | order Dactinomycin | Dactinomycin chemical structure | Dactinomycin in vivo | Dactinomycin in vitro | Dactinomycin formula | Dactinomycin molecular weight
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