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Geraniol

Geraniol
geraniol provides a potent protective effect against cardiac dysfunction induced by diabetes. This ameliorative effect could be attributed to its suppression of oxidative stress.
Catalog No. T5665Cas No. 106-24-1
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Geraniol

Catalog No. T5665Cas No. 106-24-1

geraniol provides a potent protective effect against cardiac dysfunction induced by diabetes. This ameliorative effect could be attributed to its suppression of oxidative stress.
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Pack SizePriceAvailabilityQuantity
100 mg$46In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
geraniol provides a potent protective effect against cardiac dysfunction induced by diabetes. This ameliorative effect could be attributed to its suppression of oxidative stress.
In vivo
Geraniol prevented any increase in QTc and T-peak-T-end intervals, and markers of LV ischemia and arrhythmogenesis, seen in diabetic animals. Geraniol suppressed the exaggerated oxidative stress as evidenced by preventing the increase in 8-isoprotane. In diabetic heart tissue, geraniol prevented the inhibition in catalase activity but did not affect the heart SOD. Geraniol partially reduced hyperglycemia, prevented the hypercholesterolemia, but did not affect the serum level of adiponectin in diabetic animals.
Animal Research
Diabetes was induced in rats by a single streptozotocin injection. In the treated group,geraniol (150mg/kg/day) was administered orally starting from the 15th day after induction of diabetes, and ending after 7 weeks; diabetic control rats were given vehicle for the same period. At the end of the study, cardiac contractility was assessed by using a Millar microtip catheter in anesthetised rats, and cardiac conductivity determined by a surface ECG. Serum levels of glucose, cholesterol, triglyceride and adiponectin as well as urine 8-isoprostane were determined
Chemical Properties
Molecular Weight154.25
FormulaC10H18O
Cas No.106-24-1
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (178.28 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.4830 mL32.4149 mL64.8298 mL324.1491 mL
5 mM1.2966 mL6.4830 mL12.9660 mL64.8298 mL
10 mM0.6483 mL3.2415 mL6.4830 mL32.4149 mL
20 mM0.3241 mL1.6207 mL3.2415 mL16.2075 mL
50 mM0.1297 mL0.6483 mL1.2966 mL6.4830 mL
100 mM0.0648 mL0.3241 mL0.6483 mL3.2415 mL

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