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Anti-Endothelin B Receptor Antibody (9N820)

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Catalog No. TMAC-01292

Anti-Endothelin B Receptor Antibody (9N820) is a Rabbit antibody targeting Endothelin B Receptor. Anti-Endothelin B Receptor Antibody (9N820) can be used in WB,IP.

Anti-Endothelin B Receptor Antibody (9N820)

Anti-Endothelin B Receptor Antibody (9N820)

😃Good
Catalog No. TMAC-01292
Anti-Endothelin B Receptor Antibody (9N820) is a Rabbit antibody targeting Endothelin B Receptor. Anti-Endothelin B Receptor Antibody (9N820) can be used in WB,IP.
Pack SizePriceAvailabilityQuantity
50 μL$2977-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-Endothelin B Receptor Antibody (9N820) is a Rabbit antibody targeting Endothelin B Receptor. Anti-Endothelin B Receptor Antibody (9N820) can be used in WB,IP.
Ig Type
IgG
Reactivity
Human,zebrafish
Application
Recommended Dose
WB: 1:500-2000; IP: 1:10-50
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundEndothelin receptor B (ETBR), also known as EDNRB, ETB, ETRB, HSCR and HSCR2, is a member of the guanine-binding, regulatory protein-coupled receptor family. Three isoforms of ETBR exist called isoform 1, isoform 2 and δ 3. ETBR is involved in the regulation of sodium excretion and glomular filtration rate (GFR). ETBR plays a role in the normal development of the neural crestderived cell lineages, epidermal melanocytes and enteric neurons. ETBR is expressed in lung, kidney, placenta, skeletal muscle and stem villi vessels. Both of the ET receptors, ETAR and ETBR, are activated by ET1, which results in inhibition of active lens sodium-potassium transport. Activation of the ET receptors also causes an increase in cytoplasmic calcium concentration in cultured lens epithelial cells. ETBR deficiency causes early onset dysfunction of the kidney, characterized by reduced sodium excretion, decreased GFR and slightly elevated blood pressure. Mutations in the gene encoding ETBR produce congenital aganglionic megacolon and pigment abnormalities. The multigenic disorder, Hirschsprung??s disease type 2, is also due to a mutation in the ETBR gene.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Antigen Species
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 50 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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