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Anti-Claudin 2 Antibody (3U888)
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Catalog No. TMAB-04424
Anti-Claudin 2 Antibody (3U888) is a Mouse antibody targeting Claudin 2. Anti-Claudin 2 Antibody (3U888) can be used in IHC-P,IHC-Fr,IF.
Anti-Claudin 2 Antibody (3U888)
Anti-Claudin 2 Antibody (3U888)
Copy Product Info😃Good
Catalog No. TMAB-04424
Anti-Claudin 2 Antibody (3U888) is a Mouse antibody targeting Claudin 2. Anti-Claudin 2 Antibody (3U888) can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Claudin 2 Antibody (3U888) is a Mouse antibody targeting Claudin 2. Anti-Claudin 2 Antibody (3U888) can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 3U888 |
| Reactivity | Human (predicted:Mouse,Rat) |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (Human gallbladder); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (Claudin 2) Monoclonal Antibody, Unconjugated (TMAB-04424) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Mouse) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cell junction; tight junction. Cell membrane. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-2, also known as CLDN2 or SP82, is a 230 amino acid multi-pass membrane protein that localizes to the cell junctions and belongs to the claudin superfamily. Able to form homopolymers of heteropolymers with other claudin family members, claudin-2 plays an essential role in mediating calcium-independent cell-adhesion activity that is necessary for tight junction-specific obliteration of the intercellular space. Overexpression of claudin-2 is associated with a variety of diseases, including lung cancer, colorectal cancer, gastrointestinal carcinomas and inflammatory bowel disease, further affirming the importance of claudin-2 in cell adhesion. The gene encoding claudin-2 maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes. |
| Immunogen | KLH conjugated synthetic peptide: human Claudin 2 |
| Antigen Species | Human |
| Gene Name | CLDN2 |
| Gene ID | |
| Protein Name | Claudin-2 |
| Uniprot ID | |
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
| Molecular Weight | Theoretical: 25 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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