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Anti-Claudin 2 Antibody (3U888)

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Catalog No. TMAB-04424

Anti-Claudin 2 Antibody (3U888) is a Mouse antibody targeting Claudin 2. Anti-Claudin 2 Antibody (3U888) can be used in IHC-P,IHC-Fr,IF.

Anti-Claudin 2 Antibody (3U888)

Anti-Claudin 2 Antibody (3U888)

😃Good
Catalog No. TMAB-04424
Anti-Claudin 2 Antibody (3U888) is a Mouse antibody targeting Claudin 2. Anti-Claudin 2 Antibody (3U888) can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
200 μg$1,0597-10 days7-10 days
50 μL$2227-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Claudin 2 Antibody (3U888) is a Mouse antibody targeting Claudin 2. Anti-Claudin 2 Antibody (3U888) can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Clone
3U888
Reactivity
Human (predicted:Mouse,Rat)
Application
IHC-P
IHC-Fr
IF
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationCell junction; tight junction. Cell membrane.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-2, also known as CLDN2 or SP82, is a 230 amino acid multi-pass membrane protein that localizes to the cell junctions and belongs to the claudin superfamily. Able to form homopolymers of heteropolymers with other claudin family members, claudin-2 plays an essential role in mediating calcium-independent cell-adhesion activity that is necessary for tight junction-specific obliteration of the intercellular space. Overexpression of claudin-2 is associated with a variety of diseases, including lung cancer, colorectal cancer, gastrointestinal carcinomas and inflammatory bowel disease, further affirming the importance of claudin-2 in cell adhesion. The gene encoding claudin-2 maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Claudin 2
Antigen Species
Human
Gene Name
CLDN2
Gene ID
9075
Protein Name
Claudin-2
Uniprot ID
P57739
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Chemical Properties
Molecular WeightTheoretical: 25 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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