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SR0987

Name: SR0987
Brand: TargetMol
SKU: T4670
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4670Cas No. 303126-97-8

Alias LYC-53772

SR0987 is a RORγt agonist,

SR0987

🥰Excellent

Purity: 99.43%

Catalog No. T4670Alias LYC-53772Cas No. 303126-97-8

SR0987 is a RORγt agonist,

Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$54	In Stock
10 mg	$93	In Stock
25 mg	$198	In Stock
50 mg	$347	In Stock
100 mg	$515	In Stock
200 mg	$733	In Stock
1 mL x 10 mM (in DMSO)	$60	In Stock

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Batch Information

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Purity:99.43%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SR0987 is a RORγt agonist,
Targets&IC50	RORγt:800 nM (EC50)
In vitro	Treatment with SR0987 leads to a significant decrease in the surface expression of PD-1, while desmosterol shows no impact on this parameter. Co-treatment with SR0987 and desmosterol suggests a potential increase in IL17 production. Additionally, SR0987 exhibits a concentration-dependent stimulation of reporter gene expression, achieving an effective concentration (EC50) of approximately 800nM.
Synonyms	LYC-53772

Chemical Properties

Molecular Weight	397.7
Formula	C₁₆H₁₀ClF₆NO₂
Cas No.	303126-97-8
Smiles	OC(c1ccc(NC(=O)c2ccccc2Cl)cc1)(C(F)(F)F)C(F)(F)F
Relative Density.	1.525 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (113.15 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5145 mL	12.5723 mL	25.1446 mL	125.7229 mL
5 mM	0.5029 mL	2.5145 mL	5.0289 mL	25.1446 mL
10 mM	0.2514 mL	1.2572 mL	2.5145 mL	12.5723 mL
20 mM	0.1257 mL	0.6286 mL	1.2572 mL	6.2861 mL
50 mM	0.0503 mL	0.2514 mL	0.5029 mL	2.5145 mL
100 mM	0.0251 mL	0.1257 mL	0.2514 mL	1.2572 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc