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Anti-JDP2 Polyclonal Antibody
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Catalog No. TMAB-01007
Alias Progesterone receptor co-activator, JUNDM2, Jun dimerization protein 2, JDP 2
Anti-JDP2 Polyclonal Antibody is a Rabbit antibody targeting JDP2. Anti-JDP2 Polyclonal Antibody can be used in WB.
Anti-JDP2 Polyclonal Antibody
Anti-JDP2 Polyclonal Antibody
😃Good
Catalog No. TMAB-01007Alias Progesterone receptor co-activator, JUNDM2, Jun dimerization protein 2, JDP 2
Anti-JDP2 Polyclonal Antibody is a Rabbit antibody targeting JDP2. Anti-JDP2 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-JDP2 Polyclonal Antibody is a Rabbit antibody targeting JDP2. Anti-JDP2 Polyclonal Antibody can be used in WB. |
| Synonyms | Progesterone receptor co-activator, JUNDM2, Jun dimerization protein 2, JDP 2 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) |
| Verified Activity | Sample: Lane 1: Mouse Testis tissue lysates Lane 2: Rat Testis tissue lysates Lane 3: Human HepG2 cell lysates Lane 4: Human DU145 cell lysates Lane 5: Human HeLa cell lysates Primary: Anti-JDP2 (TMAB-01007) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 19 kDa Observed band size: 22 kDa  |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | c-Jun dimerization protein (JDP) 2 binds cAMP-response element (CRE) as a homodimer or as a heterodimer with ATF-2 and c-Jun. This dimerization allows JDP2 to repress CRE-dependent transcription. JDP2 is phosphorylated by c-Jun N-terminal kinase at Thr 138. JDP2 contains a basic leucine zipper (bZIP) region for DNA-binding. The bZIP region of JDP2 interacts with the DNA binding domain (DBD) of progesterone receptor (PR) in mammalian cells. Two other coactivators, creb binding protein (CBP) and p300 CBP-associated factor (PCAF), also associate with JDP2. Thus, JDP2 appears to stimulate the N-terminal activation function domain of PR by docking to the DBD and facilitation PR interaction with other coactivators. The expression of JDP2 in PR-targeted tissues and cells supports the role for JDP2 in PR function. In addition, JDP2 may play an important role in controlling the commitment of F9 embryonal carcinoma cells to differentiation. In undifferentiated F9 cells, JDP2 recruits HDAC3 and binds the differentiation response element within the c-jun promoter. Retinoic acid-induction replaces the JDP2/HDAC3 complex with PCAF and subsequently allows the transcription of c-Jun for F9 differentiation. The gene encoding human JDP2 maps to chromosome 14q24.2. |
| Immunogen | KLH conjugated synthetic peptide: human JDP2 |
| Antigen Species | Human |
| Gene Name | JDP2 |
| Gene ID | |
| Protein Name | Jun dimerization protein 2 |
| Uniprot ID | |
| Biology Area | Leucine Zipper |
| Function | Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. |
| Molecular Weight | Theoretical: 19 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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