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Seribantumab
😃Good
Catalog No. T76791Cas No. 1334296-12-6
Alias SAR-256212, SAR256212, MM-121, MM121
Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting NRG1-induced growth in MCF-7 cells and patient-derived breast and lung cancer cells harboring NRG1 fusions or amplifications. It also induces apoptosis in MDA-MB-175-VII and LUAD-0061AS3 cells.
Seribantumab
Seribantumab
😃Good
Catalog No. T76791Alias SAR-256212, SAR256212, MM-121, MM121Cas No. 1334296-12-6
Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting NRG1-induced growth in MCF-7 cells and patient-derived breast and lung cancer cells harboring NRG1 fusions or amplifications. It also induces apoptosis in MDA-MB-175-VII and LUAD-0061AS3 cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $78 | In Stock | In Stock | |
| 5 mg | $237 | In Stock | In Stock | |
| 10 mg | $383 | - | In Stock | |
| 25 mg | $629 | - | In Stock | |
| 50 mg | $889 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:96.26% (SEC-HPLC)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
| Description | Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting NRG1-induced growth in MCF-7 cells and patient-derived breast and lung cancer cells harboring NRG1 fusions or amplifications. It also induces apoptosis in MDA-MB-175-VII and LUAD-0061AS3 cells. |
| Targets&IC50 | LUAD-0061AS3 cell:1.4 μM, MCF-7 cells:45.2 μM, MDA-MB-175-VII cells:0.02 μM, HBECp53 cell:203 μM |
| In vitro | Methods: seribantumab (0.1, 1, 10 μM) was used to treat cancer cells. Results: seribantumab inhibited neuregulin (NRG1) fusion dependent tumorigenosis. The IC50 values of Seribantumab for MDA-MB-175-VII cells, LUAD-0061AS3 cells, MCF-7 cells, and HBECp53 cells were 0.02 μM, 1.4 μM, 45.2 μM, and 203 μM, respectively. [1] |
| In vivo | Seribantumab (0.6 mg, 0.75 mg, or 1 mg per dose twice weekly) was injected into mice with LUAD-0061AS3 PDX tumors, and results showed that seribantumab was more effective than afatinib in reducing tumor growth. [1] |
| Synonyms | SAR-256212, SAR256212, MM-121, MM121 |
| Reactivity | Human |
| Verified Activity | Immobilized Human HER3 Protein (His) at 2 μg/mL (30 μL/well) can bind Seribantumab. The EC50 is 0.01214 μg/mL. |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | ERBB3/HER3 |
| Molecular Weight | 143.14 kDa |
| Cas No. | 1334296-12-6 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG2 lambda |
| Recommended Isotype Control |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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