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Seribantumab (Synonyms: SAR-256212, SAR256212, MM-121, MM121)
Catalog No. T76791 Copy Product Info
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Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting NRG1-induced growth in MCF-7 cells and patient-derived breast and lung cancer cells harboring NRG1 fusions or amplifications. It also induces apoptosis in MDA-MB-175-VII and LUAD-0061AS3 cells.
Seribantumab
Copy Product Info🥰Excellent
Catalog No. T76791
Synonyms SAR-256212, SAR256212, MM-121, MM121
Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting NRG1-induced growth in MCF-7 cells and patient-derived breast and lung cancer cells harboring NRG1 fusions or amplifications. It also induces apoptosis in MDA-MB-175-VII and LUAD-0061AS3 cells.
Seribantumab
Cas No. 1334296-12-6
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $78 | In Stock | In Stock | |
| 5 mg | $237 | In Stock | In Stock | |
| 10 mg | $383 | - | In Stock | |
| 25 mg | $629 | - | In Stock | |
| 50 mg | $889 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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Purity:96.26% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting NRG1-induced growth in MCF-7 cells and patient-derived breast and lung cancer cells harboring NRG1 fusions or amplifications. It also induces apoptosis in MDA-MB-175-VII and LUAD-0061AS3 cells. |
| Targets&IC50 | LUAD-0061AS3 cell:1.4 μM, MDA-MB-175-VII cells:0.02 μM, HBECp53 cell:203 μM, MCF-7 cells:45.2 μM |
| In vitro | Methods: seribantumab (0.1, 1, 10 μM) was used to treat cancer cells. Results: seribantumab inhibited neuregulin (NRG1) fusion dependent tumorigenosis. The IC50 values of Seribantumab for MDA-MB-175-VII cells, LUAD-0061AS3 cells, MCF-7 cells, and HBECp53 cells were 0.02 μM, 1.4 μM, 45.2 μM, and 203 μM, respectively. [1] |
| In vivo | Seribantumab (0.6 mg, 0.75 mg, or 1 mg per dose twice weekly) was injected into mice with LUAD-0061AS3 PDX tumors, and results showed that seribantumab was more effective than afatinib in reducing tumor growth. [1] |
| Synonyms | SAR-256212, SAR256212, MM-121, MM121 |
| Reactivity | Human |
| Verified Activity | Immobilized Human HER3 Protein (His) at 2 μg/mL (30 μL/well) can bind Seribantumab. The EC50 is 0.01214 μg/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | ERBB3/HER3 |
| Molecular Weight | 143.14 kDa |
| Cas No. | 1334296-12-6 |
| Isotype | Human IgG2 lambda |
| Recommended Isotype Control |
| Storage | -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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