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Anti-MDM2 Antibody (6Z692)
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Catalog No. TMAC-02509
Alias RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2, Oncoprotein Mdm2, Mdm2, E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein
Anti-MDM2 Antibody (6Z692) is a Mouse antibody targeting MDM2. Anti-MDM2 Antibody (6Z692) can be used in WB,IP,IF,IHC-P.
Anti-MDM2 Antibody (6Z692)
Anti-MDM2 Antibody (6Z692)
😃Good
Catalog No. TMAC-02509Alias RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2, Oncoprotein Mdm2, Mdm2, E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein
Anti-MDM2 Antibody (6Z692) is a Mouse antibody targeting MDM2. Anti-MDM2 Antibody (6Z692) can be used in WB,IP,IF,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $426 | 7-10 days |
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Chemical Properties
| Description | Anti-MDM2 Antibody (6Z692) is a Mouse antibody targeting MDM2. Anti-MDM2 Antibody (6Z692) can be used in WB,IP,IF,IHC-P. |
| Synonyms | RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2, Oncoprotein Mdm2, Mdm2, E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein |
| Clone | 6Z692 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of MDM2 expression in U-2OS (A), A-673 (B) and RAW 264.7 (C) whole cell lysates. |
| Application | |
| Recommended Dose | WB: 1:100-1000; IHC-P: 1:50-500; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. These findings argue that MDM2 overexpression represents at least one mechanism by which p53 function can be abrogated during tumorigenesis. |
| Conjucates | Unconjugated |
| Immunogen | Amino acids 154-167 of MDM2 of human origin |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 90 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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