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Anti-BRCA2 Polyclonal Antibody 3
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Catalog No. TMAB-03208
Anti-BRCA2 Polyclonal Antibody 3 is a Rabbit antibody targeting BRCA2. Anti-BRCA2 Polyclonal Antibody 3 can be used in ICC/IF.
Anti-BRCA2 Polyclonal Antibody 3
Anti-BRCA2 Polyclonal Antibody 3
😃Good
Catalog No. TMAB-03208
Anti-BRCA2 Polyclonal Antibody 3 is a Rabbit antibody targeting BRCA2. Anti-BRCA2 Polyclonal Antibody 3 can be used in ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-BRCA2 Polyclonal Antibody 3 is a Rabbit antibody targeting BRCA2. Anti-BRCA2 Polyclonal Antibody 3 can be used in ICC/IF. |
| Ig Type | IgG |
| Reactivity | Human |
| Application | |
| Recommended Dose | ICC/IF: 1:50-200 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nuclear protein. |
| Tissue Specificity | Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both genes is exon 11, which harbors the most important and frequent mutations in breast cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, May 2020] |
| Immunogen | KLH conjugated synthetic peptide: human BRCA2 |
| Antigen Species | Human |
| Gene Name | BRCA2 |
| Gene ID | |
| Protein Name | Breast cancer type 2 susceptibility protein |
| Uniprot ID | |
| Function | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. In concert with NPM1, regulates centrosome duplication. |
| Molecular Weight | Theoretical: 384 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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