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VLX1570

Name: VLX1570
Brand: TargetMol
SKU: T4067
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4067Cas No. 1431280-51-1

VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 ranging from 4.2 μM to 8.6 μM, and exhibits potent inhibition of USP14.

VLX1570

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Purity: 99.91%

Catalog No. T4067Cas No. 1431280-51-1

VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 ranging from 4.2 μM to 8.6 μM, and exhibits potent inhibition of USP14.

Pack Size	Price	Availability
1 mg	$97	In Stock
2 mg	$157	In Stock
5 mg	$272	In Stock
10 mg	$428	In Stock
25 mg	$716	In Stock
50 mg	$987	In Stock
100 mg	$1,370	In Stock
1 mL x 10 mM (in DMSO)	$279	In Stock

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Batch Information

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Purity:99.91%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 ranging from 4.2 μM to 8.6 μM, and exhibits potent inhibition of USP14.
Targets&IC50	DUB:4.2-8.6 μM

Chemical Properties

Molecular Weight	469.39
Formula	C₂₃H₁₇F₂N₃O₆
Cas No.	1431280-51-1
Smiles	[O-][N+](=O)c1cc(\C=C2\CCN(C\C(=C\c3ccc(F)c(c3)[N+]([O-])=O)C2=O)C(=O)C=C)ccc1F
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32 mg/mL (68.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1304 mL	10.6521 mL	21.3042 mL	106.5212 mL
5 mM	0.4261 mL	2.1304 mL	4.2608 mL	21.3042 mL
10 mM	0.2130 mL	1.0652 mL	2.1304 mL	10.6521 mL
20 mM	0.1065 mL	0.5326 mL	1.0652 mL	5.3261 mL
50 mM	0.0426 mL	0.2130 mL	0.4261 mL	2.1304 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc