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Anti-Claudin-2 Polyclonal Antibody
😃Good
Catalog No. TMAB-00441
Alias SP82, SP 82, OTTHUMP00000023793, CLDN2, CLDN 2, CLD2, Claudin2
Anti-Claudin-2 Polyclonal Antibody is a Rabbit antibody targeting Claudin-2. Anti-Claudin-2 Polyclonal Antibody can be used in WB.
Anti-Claudin-2 Polyclonal Antibody
Anti-Claudin-2 Polyclonal Antibody
😃Good
Catalog No. TMAB-00441Alias SP82, SP 82, OTTHUMP00000023793, CLDN2, CLDN 2, CLD2, Claudin2
Anti-Claudin-2 Polyclonal Antibody is a Rabbit antibody targeting Claudin-2. Anti-Claudin-2 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Claudin-2 Polyclonal Antibody is a Rabbit antibody targeting Claudin-2. Anti-Claudin-2 Polyclonal Antibody can be used in WB. |
| Synonyms | SP82, SP 82, OTTHUMP00000023793, CLDN2, CLDN 2, CLD2, Claudin2 |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| Verified Activity | Sample: A549 (Human) Cell Lysate at 30 μg Primary: Anti-Claudin 2 (TMAB-00441) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 25 kDa Observed band size: 25 kDa  |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell junction; tight junction. Cell membrane. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-2, also known as CLDN2 or SP82, is a 230 amino acid multi-pass membrane protein that localizes to the cell junctions and belongs to the claudin superfamily. Able to form homopolymers of heteropolymers with other claudin family members, claudin-2 plays an essential role in mediating calcium-independent cell-adhesion activity that is necessary for tight junction-specific obliteration of the intercellular space. Overexpression of claudin-2 is associated with a variety of diseases, including lung cancer, colorectal cancer, gastrointestinal carcinomas and inflammatory bowel disease, further affirming the importance of claudin-2 in cell adhesion. The gene encoding claudin-2 maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes. |
| Immunogen | KLH conjugated synthetic peptide: human Claudin 2 |
| Antigen Species | Human |
| Gene Name | CLDN2 |
| Gene ID | |
| Protein Name | Claudin-2 |
| Uniprot ID | |
| Biology Area | Tight Junctions |
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
| Molecular Weight | Theoretical: 25 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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