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Corynoxine

Name: Corynoxine
Brand: TargetMol
SKU: T5S0658
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S0658Cas No. 6877-32-3

Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla. It is an autophagy enhancer that promotes α-synuclein clearance through the Akt/mTOR pathway.

Corynoxine

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Purity: 99.93%

Catalog No. T5S0658Cas No. 6877-32-3

Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla. It is an autophagy enhancer that promotes α-synuclein clearance through the Akt/mTOR pathway.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$90	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$215	In Stock	In Stock
50 mg	$318	In Stock	In Stock
100 mg	$469	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$100	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White to Red

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Corynoxine AI Summary

Corynoxine exhibits no significant cytotoxicity against human HL60 and SW480 cells at 48 hours, as determined by the MTT assay, with an IC50 value greater than 40000 nM. It demonstrates vasodilatory activity in Sprague-Dawley rat thoracic aorta smooth muscle by inhibiting phenylephrine-induced and KCl-induced vasoconstriction with an IC50 value greater than 30 µg/mL in both assays. Corynoxine also shows high affinity for opioid receptors, particularly mu opioid receptors, with a Ki value of 16.4 nM. It displaces ligands from delta and kappa opioid receptors, achieving 80.1% displacement of [3H]DAMGO from mu opioid receptors at 100 nM and 97.8% at 10000 nM after 120 minutes. The compound also displays significant displacement of [3H]DADLE from delta receptors and [3H]U69593 from kappa receptors. In terms of antinociceptive activity, it has an ED50 of 6.75 mg/kg in Sprague-Dawley rats, as assessed by the Hot-plate test. Additionally, Corynoxine shows good stability and high drug recovery rates (>90.0%) in rat plasma under various conditions, including benchtop testing, autosampler analysis, freeze-thaw cycles, and storage at -80°C, indicating its potential suitability for pharmaceutical use..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla. It is an autophagy enhancer that promotes α-synuclein clearance through the Akt/mTOR pathway.

Chemical Properties

Molecular Weight	384.47
Formula	C₂₂H₂₈N₂O₄
Cas No.	6877-32-3
Smiles	CC[C@@H]1CN2CC[C@]3([C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC)C(=O)Nc1ccccc31
Relative Density.	1.23 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 50 mg/mL (130.05 mM), Sonication is recommended.

H2O: Insoluble

DMSO: 55 mg/mL (143.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6010 mL	13.0049 mL	26.0098 mL	130.0492 mL
5 mM	0.5202 mL	2.6010 mL	5.2020 mL	26.0098 mL
10 mM	0.2601 mL	1.3005 mL	2.6010 mL	13.0049 mL
20 mM	0.1300 mL	0.6502 mL	1.3005 mL	6.5025 mL
50 mM	0.0520 mL	0.2601 mL	0.5202 mL	2.6010 mL
100 mM	0.0260 mL	0.1300 mL	0.2601 mL	1.3005 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc