Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Antifungal agent 38 is a geterocyclic disulfide with antifungal and antibacterial activity. Antifungal agent 38 induces the shrinkage of hyphae, disrupts the integrity of the plasma membrane, and causes the damage and leakage of cell contents [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | Antifungal agent 38 is a geterocyclic disulfide with antifungal and antibacterial activity. Antifungal agent 38 induces the shrinkage of hyphae, disrupts the integrity of the plasma membrane, and causes the damage and leakage of cell contents [1]. |
In vitro | Antifungal agent 38 demonstrates significant antifungal efficacy at a concentration of 50 μg/mL, inhibiting the growth of 10 pathogenic fungi with rates ranging from 37.32% (M. oryzae) to 100% (S. sclerotiorum, A. flavus, M. fructicola) [1]. At a lower dose of 5 μg/mL, it compromises the plasma membrane integrity of M. fructicola, while at 100 μg/mL, it exhibits strong antibacterial activity against X. oryzae accc 11602 and X. axonpodis [1]. Its inhibitory concentration (EC50) values against various fungi include 17.09 μg/mL (R. solani), 6.34 μg/mL (S. sclerotiorum), and over 10 μg/mL for (A. flavus), indicating a potent fungicidal action [1]. Furthermore, a cell viability assay on M. fructicola across concentrations of 10, 25, and 50 μg/mL over periods of 2, 4, and 6 days confirmed its growth inhibition [1]. |
In vivo | Antifungal agent 38 (compound S8), at a concentration of 200 μg/mL, exhibits effects similar to the positive control, Thiophanate-Methyl, in curing and superior efficacy in prevention in vivo [1]. When applied to pears in doses of 50, 100, and 200 μg/mL (30 mL; sprinkling), it effectively inhibits the growth of M. fructicola in vivo [1]. |
Molecular Weight | 200.32 |
Formula | C8H12N2S2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Antifungal agent 38 inhibitor inhibit