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FPI-1523 sodium

Name: FPI-1523 sodium
Brand: TargetMol
SKU: T38941
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38941Cas No. 1452459-52-7

FPI-1523 sodium, a derivative of avibactam, is a potent β-lactamase inhibitor with Kd values of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. It inhibited PBP2 with an IC50 of 3.2 μM and has a high level of antibacterial and considerable antimicrobial activity.

FPI-1523 sodium

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Catalog No. T38941Cas No. 1452459-52-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	-	In Stock
5 mg	$98	-	In Stock
10 mg	$158	-	In Stock
25 mg	$323	-	In Stock
50 mg	$461	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:White

Resource Download

COA HNMR MS

Product Introduction

Bioactivity

Description

In vitro

FPI-1523 sodium effectively inhibits both E. coli K12 and its PBP2, displaying minimum inhibitory concentrations (MIC) and half-maximal inhibitory concentrations (IC50) of 4 μg/mL and 0.4 μg/mL, respectively. Additionally, it demonstrates potent inhibition against E. coli BW25113 pGDP-2 transformants, irrespective of the presence of an empty vector or the expression of various β-lactamases, achieving low MIC values (1-2 μM).[1]

Chemical Properties

Molecular Weight	344.27
Formula	C₉H₁₃N₄NaO₇S
Cas No.	1452459-52-7
Smiles	CC(NNC([C@H]1[N@@]2C(N([C@@](CC1)([H])C2)OS(=O)([O-])=O)=O)=O)=O.[Na+]

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (130.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9047 mL	14.5235 mL	29.0470 mL	145.2348 mL
5 mM	0.5809 mL	2.9047 mL	5.8094 mL	29.0470 mL
10 mM	0.2905 mL	1.4523 mL	2.9047 mL	14.5235 mL
20 mM	0.1452 mL	0.7262 mL	1.4523 mL	7.2617 mL
50 mM	0.0581 mL	0.2905 mL	0.5809 mL	2.9047 mL
100 mM	0.0290 mL	0.1452 mL	0.2905 mL	1.4523 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc