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SIRT6-IN-5

Name: SIRT6-IN-5
Brand: TargetMol
SKU: T24793
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24793Cas No. 891002-11-2

Alias SIRT6 inhibitor-5, SIRT6 inhibitor5, SIRT6 inhibitor 5, SIRT6 IN 5

SIRT6-IN-5(SIRT6 inhibitor 5) is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increases H3K9 acetylation and glucose uptake in cultured cells, and reduces T-cell proliferation.

SIRT6-IN-5

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Purity: 98.77%

Catalog No. T24793Alias SIRT6 inhibitor-5, SIRT6 inhibitor5, SIRT6 inhibitor 5, SIRT6 IN 5Cas No. 891002-11-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$397	In Stock	In Stock
50 mg	$788	In Stock	In Stock
100 mg	$1,070	In Stock	In Stock
500 mg	$2,130	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.77%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

SIRT6-IN-5 AI Summary

SIRT6-IN-5 shows potent inhibition of SIRT6 with 100% inhibition at 200µM and an IC50 value of 34000nM. It also inhibits SIRT1 and SIRT2 with IC50 values of 783000nM and 453000nM, respectively, giving selectivity indices of 23.02 and 13.32 for SIRT1 and SIRT2 relative to SIRT6. In human BxPC3 cells, SIRT6-IN-5 increases H3K9 acetylation, enhances glucose uptake, and inhibits TNFalpha production. The compound has a pKa of 2.58, a logP of 2.6, and moderate aqueous solubility. It has low fractions unbound in human and mouse plasma. The pharmacokinetic parameters in ICR mice include AUC, MRT, half-life, Tmax, and Cmax..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SIRT6-IN-5(SIRT6 inhibitor 5) is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increases H3K9 acetylation and glucose uptake in cultured cells, and reduces T-cell proliferation.
Targets&IC50	SIRT6:34 μM
Synonyms	SIRT6 inhibitor-5, SIRT6 inhibitor5, SIRT6 inhibitor 5, SIRT6 IN 5

Chemical Properties

Molecular Weight	366.32
Formula	C₁₉H₁₄N₂O₆
Cas No.	891002-11-2
Smiles	N(C(=O)C1=CC=C(NC(=O)C2=CC=CO2)C=C1)C3=CC(C(O)=O)=C(O)C=C3
Relative Density.	1.520 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (150.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7299 mL	13.6493 mL	27.2985 mL	136.4927 mL
5 mM	0.5460 mL	2.7299 mL	5.4597 mL	27.2985 mL
10 mM	0.2730 mL	1.3649 mL	2.7299 mL	13.6493 mL
20 mM	0.1365 mL	0.6825 mL	1.3649 mL	6.8246 mL
50 mM	0.0546 mL	0.2730 mL	0.5460 mL	2.7299 mL
100 mM	0.0273 mL	0.1365 mL	0.2730 mL	1.3649 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc