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p-Fluoro-L-phenylalanine

Name: p-Fluoro-L-phenylalanine
Brand: TargetMol
SKU: T41274
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41274Cas No. 1132-68-9

p-Fluoro-L-phenylalanine is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli with an KD of 0.26 μM.

p-Fluoro-L-phenylalanine

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Purity: 99.63%

Catalog No. T41274Cas No. 1132-68-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock

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Purity:99.63%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

p-Fluoro-L-phenylalanine AI Summary

p-Fluoro-L-phenylalanine exhibits antiplasmodial activity against different strains of Plasmodium falciparum, with IC50 values ranging from 10000.0 nM to 15848.93 nM after 72 hours as determined by the SYBR green assay. It shows differential inhibition of Plasmodium falciparum lines 3D7, W2, GB4, 7G8, D10, and HB3 at varying potencies. Additionally, p-Fluoro-L-phenylalanine modulates human peripheral myelin protein 22 (PMP22) expression/activity, activates Rab9 and NPC1 promoters, and inhibits aldehyde dehydrogenase 1 (ALDH1A1) activity. It also interferes with histone lysine methyltransferase G9a and HP1-beta chromodomain interactions with methylated histone tails, displaying potential as an inhibitor of delayed death in malarial parasites as well as B-cell receptor signaling. Furthermore, p-Fluoro-L-phenylalanine inhibits hERG channel activity and shows effectiveness against Marburg Virus by inhibiting binding or entry into cells. The compound has a LogD7.4 value of -1.06, indicating its distribution coefficient in an octan-1-ol/water system at pH 7.4, within the experimental range of -1.5 to 4.5..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	183.18
Formula	C₉H₁₀FNO₂
Cas No.	1132-68-9
Smiles	N[C@@H](Cc1ccc(F)cc1)C(O)=O
Relative Density.	1.293 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 8 mg/mL (43.67 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.4591 mL	27.2956 mL	54.5911 mL	272.9556 mL
5 mM	1.0918 mL	5.4591 mL	10.9182 mL	54.5911 mL
10 mM	0.5459 mL	2.7296 mL	5.4591 mL	27.2956 mL
20 mM	0.2730 mL	1.3648 mL	2.7296 mL	13.6478 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc