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Tilorone dihydrochloride

Name: Tilorone dihydrochloride
Brand: TargetMol
SKU: T0244
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0244Cas No. 27591-69-1

Tilorone dihydrochloride, an orally active interferon inducer, exhibits both antineoplastic and anti-inflammatory actions.

Tilorone dihydrochloride

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Purity: 99.86%

Catalog No. T0244Cas No. 27591-69-1

Tilorone dihydrochloride, an orally active interferon inducer, exhibits both antineoplastic and anti-inflammatory actions.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$34	In Stock	In Stock
100 mg	$48	In Stock	-
200 mg	$86	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.86%

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COA HNMR LCMS

Product Introduction

Tilorone dihydrochloride AI Summary

Tilorone dihydrochloride has diverse biological activities, particularly in antiviral and anticancer applications. It inhibits the DNA polymerase activity of the Moloney murine leukemia virus with an ID50 of 75.0 µg/mL. The compound exhibits antiviral activity against the Vesicular stomatitis virus in both pig EPT cells and mouse L929 cells, significantly inhibiting the virus-induced cytopathic effect with IC50 values ranging from 1318.26 nM to 13803.84 nM. The selectivity index ratios of CC50 to IC50 range from 10.0 to 80.0, depending on the cell type and treatment conditions. Furthermore, it induces interferon (IFN) activity in both mouse L929 cells and pig EPT cells with an activity level of 32.0. Cytotoxicity studies showed pCC50 values of 3.95 to 3.97 after 24 to 48 hours, indicating moderate toxicity. Tilorone dihydrochloride also demonstrates cytotoxic effects on African green monkey Vero cells, human HEK293T cells, and anticancer activity against human HeLa, Hep3B, and A549 cells after 48 hours, as measured by the MTT assay, with varying IC50 values. However, the compound exhibited low antiviral activity against SARS-CoV-2, with a hit score of 0.04106 in assays conducted in HRCE cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tilorone dihydrochloride, an orally active interferon inducer, exhibits both antineoplastic and anti-inflammatory actions.
In vivo	T0242L

Chemical Properties

Molecular Weight	483.47
Formula	C₂₅H₃₆Cl₂N₂O₃
Cas No.	27591-69-1
Smiles	CCN(CC)CCOc1cc2c(cc1)c1c(cc(OCCN(CC)CC)cc1)C2=O.Cl.Cl
Relative Density.	1.102g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 198.6 mM, Sonication is recommended.

DMSO: 4.84 mg/mL (10.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0684 mL	10.3419 mL	20.6838 mL	103.4190 mL
5 mM	0.4137 mL	2.0684 mL	4.1368 mL	20.6838 mL
10 mM	0.2068 mL	1.0342 mL	2.0684 mL	10.3419 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1034 mL	0.5171 mL	1.0342 mL	5.1710 mL
50 mM	0.0414 mL	0.2068 mL	0.4137 mL	2.0684 mL
100 mM	0.0207 mL	0.1034 mL	0.2068 mL	1.0342 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc