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Diallyl Trisulfide

Name: Diallyl Trisulfide
Brand: TargetMol
SKU: T8693
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8693Cas No. 2050-87-5

Diallyl Trisulfide is an organic polysulfide compound found in garlic that acts as an H2S donor.

Diallyl Trisulfide

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Catalog No. T8693Cas No. 2050-87-5

Diallyl Trisulfide is an organic polysulfide compound found in garlic that acts as an H2S donor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	-	In Stock
10 mg	$51	-	In Stock
25 mg	$87	-	In Stock
50 mg	$165	-	In Stock
100 mg	$310	-	In Stock
1 mL x 10 mM (in DMSO)	$195	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Diallyl Trisulfide AI Summary

Diallyl Trisulfide demonstrates multiple bioactivities, interacting with various enzymes and receptors. It inhibits human Glutathione Reductase (GR) with kinetic parameters including a Kcat value of 0.16 s^-1, a Km value of 160000.0 nM for NADPH oxidation, and a kcat/Km value of 1000.0 M^-1 s^-1. In the reduction of cytochrome c, it displays a Kcat value of 0.0011 s^-1. It acts as an agonist at the human TRPA1 channel in CHO cells with an EC50 of 490.0 nM, increasing intracellular calcium levels. The compound is a potent inhibitor of several enzymes, including Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 12589.3 nM, Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) at 39810.7 nM, 15-Hydroxyprostaglandin Dehydrogenase (HPGD) at 28183.8 nM, and the vitamin D receptor (VDR) at 25118.9 nM. Additionally, it inhibits Cytochrome P450 3A4 with a potency of 39810.7 nM and acts as both an inhibitor and substrate for this enzyme. It also inhibits GCN5L2 (22387.2 nM) and Human Apurinic/apyrimidinic Endonuclease 1 (APE1) at a potency of 100000.0 nM. Furthermore, Diallyl Trisulfide inhibits chicken liver Fatty Acid Synthase (FASN) with an IC50 of 8370.0 nM. The compound induces cell cycle arrest in MDCK cells at G1, S, G2/M, and subG1 phases with activity percentages between 26.8% and 38.6%, and demonstrates cytotoxicity against these cells with an IC50 of 50000.0 nM as determined by WST-1 assay. It also shows activity in the S16 Schwann cell viability assay with a potency of 5.1 nM. Its lipophilicity has been quantified with a LogP value of 2.98, as determined by RP-HPLC analysis at a 1 mM concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Diallyl Trisulfide is an organic polysulfide compound found in garlic that acts as an H2S donor.

Chemical Properties

Molecular Weight	178.34
Formula	C₆H₁₀S₃
Cas No.	2050-87-5
Smiles	C=CCSSSCC=C
Relative Density.	1.085 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (252.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6073 mL	28.0363 mL	56.0727 mL	280.3634 mL
5 mM	1.1215 mL	5.6073 mL	11.2145 mL	56.0727 mL
10 mM	0.5607 mL	2.8036 mL	5.6073 mL	28.0363 mL
20 mM	0.2804 mL	1.4018 mL	2.8036 mL	14.0182 mL
50 mM	0.1121 mL	0.5607 mL	1.1215 mL	5.6073 mL
100 mM	0.0561 mL	0.2804 mL	0.5607 mL	2.8036 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc