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Scoparone

Name: Scoparone
Brand: TargetMol
SKU: T2729
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2729Cas No. 120-08-1

Alias Scoparon, Escoparone, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, 6,7-dimethoxycoumarin

Scoparone (Aesculetin dimethyl ether) can be found in a number of food items such as sweet orange, wild celery, mandarin orange (clementine, tangerine), and lemon. It is found in the Chinese herb Artemisia scoparia and has been studied for its potential pharmacological properties including immunosuppression and vasorelaxation. Scoparone is found in anise. Scoparone is found in several citrus oils.

Scoparone

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Purity: 99.93%

Catalog No. T2729Alias Scoparon, Escoparone, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, 6,7-dimethoxycoumarinCas No. 120-08-1

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$93	In Stock	In Stock
100 mg	$137	In Stock	In Stock
500 mg	$342	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White to Yellow

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COA

Product Introduction

Scoparone AI Summary

Scoparone exhibits multifaceted bioactivities, including anti-inflammatory, antimicrobial, antitubercular, and antileishmanial effects. It demonstrates anti-inflammatory activity in human neutrophils by inhibiting superoxide anion generation with an IC50 as low as 8.25 µg/mL and elastase release at concentrations greater than 30,000 nM. It shows antimicrobial activity against various microorganisms with MIC values greater than 1.0 µg/mL. The compound has antitubercular activity against Mycobacterium tuberculosis H37Rv with a MIC of 388,000 nM and antileishmanial activity with EC50 values ranging from 9.11 to 27.51 µg/mL. Additionally, it shows inhibition against Clostridium histolyticum CoLH with an IC50 of 24.0 nM. Scoparone also displays cytotoxic effects against several human cell lines, including PC3 and U937 cells, with varying potencies. Its antiasthmatic effect is evidenced by the reversal of carbachol-induced contractions in tracheal rings with an EC50 of 80,000 nM. Moreover, it exhibits low cytotoxicity in some cell assays and has weak inhibitory effects on recombinant human BACE1 and the FAM-Bid peptide displacement from Mcl-1. Despite its diverse bioactivities, its effectiveness varies significantly across different assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Scoparon, Escoparone, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, 6,7-dimethoxycoumarin

Chemical Properties

Molecular Weight	206.19
Formula	C₁₁H₁₀O₄
Cas No.	120-08-1
Smiles	COc1cc2ccc(=O)oc2cc1OC
Relative Density.	1.248 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (242.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8499 mL	24.2495 mL	48.4990 mL	242.4948 mL
5 mM	0.9700 mL	4.8499 mL	9.6998 mL	48.4990 mL
10 mM	0.4850 mL	2.4249 mL	4.8499 mL	24.2495 mL
20 mM	0.2425 mL	1.2125 mL	2.4249 mL	12.1247 mL
50 mM	0.0970 mL	0.4850 mL	0.9700 mL	4.8499 mL
100 mM	0.0485 mL	0.2425 mL	0.4850 mL	2.4249 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc