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iMDK

🥰Excellent
Catalog No. T9460Cas No. 881970-80-5

iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors without harming normal cells and mice.

iMDK
Other Forms of iMDK:
iMDK quarterhydrateT61627
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iMDK

🥰Excellent
Purity: 99.99%
Catalog No. T9460Cas No. 881970-80-5
iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors without harming normal cells and mice.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$54In StockIn Stock
5 mg$128In StockIn Stock
10 mg$197In StockIn Stock
25 mg$411In StockIn Stock
50 mg$579In StockIn Stock
100 mg$803In StockIn Stock
1 mL x 10 mM (in DMSO)$139In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.99%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors without harming normal cells and mice.
In vitro
Administration of iMDK (50-500 nM) for 72 h quarterhydrate suppressed AKT phosphorylation in H441 lung adenocarcinoma cells after treatment dose-dependently. In contrast, iMDK quarterhydrate robustly increases p-ERK[1].
In vivo
Intraperitoneally injection with 100 μl of iMDK ( (9 mg/kg/day) and ; oral administion of PD0325901 (5 mg/kg) effectively reduced lung tumor growth in a xenograft mouse model[1].
Chemical Properties
Molecular Weight376.4
FormulaC21H13FN2O2S
Cas No.881970-80-5
SmilesFc1ccc(Cc2cn3cc(nc3s2)-c2cc3ccccc3oc2=O)cc1
Relative Density.1.42 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 3.77 mg/mL (10.02 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6567 mL13.2837 mL26.5675 mL132.8374 mL
5 mM0.5313 mL2.6567 mL5.3135 mL26.5675 mL
10 mM0.2657 mL1.3284 mL2.6567 mL13.2837 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

PI3KPhosphoinositide 3-kinaseNSCLCmidkineMDKInhibitorinhibitiMDKgrowthfactor
Related Tags: buy iMDK | purchase iMDK | iMDK cost | order iMDK | iMDK chemical structure | iMDK in vivo | iMDK in vitro | iMDK formula | iMDK molecular weight
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