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Asymmetric dimethylarginine

Name: Asymmetric dimethylarginine
Brand: TargetMol
SKU: T7682
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7682Cas No. 30315-93-6

Asymmetric dimethylarginine [an endogenous inhibitor of nitric oxide synthase (NOS)], is a compound that inhibits the enzyme responsible for producing nitric oxide.

Asymmetric dimethylarginine

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Purity: 99.62%

Catalog No. T7682Cas No. 30315-93-6

Asymmetric dimethylarginine [an endogenous inhibitor of nitric oxide synthase (NOS)], is a compound that inhibits the enzyme responsible for producing nitric oxide.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	In Stock	In Stock
25 mg	$89	In Stock	In Stock
50 mg	$123	In Stock	In Stock
100 mg	$162	In Stock	In Stock
200 mg	$238	In Stock	-
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.62%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Asymmetric dimethylarginine AI Summary

Asymmetric dimethylarginine exhibits a broad spectrum of bioactivity with potential implications in modulating various biological pathways and enzymatic functions. Notably, it affects dimethylarginine dimethylaminohydrolase 1 (DDAH1) activity across different species and mutants, influencing enzyme efficiency as indicated by Kcat/Km values. It exerts dual roles in the NFkB signaling pathway, acting both as an agonist and antagonist with a potency of 28183.8 nM. Additionally, it serves as an agonist for the Thyroid Stimulating Hormone Receptor, an inhibitor and substrate of Cytochrome P450 2C19, and inhibits several other enzymes including Histone Lysine Methyltransferase G9a, Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), and Human Flap endonuclease 1 (FEN1). It also enhances Arylsulfatase A (ASA1) activity and demonstrates antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 and VERO-6 cells. Furthermore, Asymmetric dimethylarginine exhibits moderate inhibition against the SARS-CoV-2 3CL-Pro protease and influences human HDAC6 enzyme activity, highlighting its multifaceted bioactivity and potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Asymmetric dimethylarginine [an endogenous inhibitor of nitric oxide synthase (NOS)], is a compound that inhibits the enzyme responsible for producing nitric oxide.

Chemical Properties

Molecular Weight	202.25
Formula	C₈H₁₈N₄O₂
Cas No.	30315-93-6
Smiles	CN(C)N=CNCCC[C@H](N)C(O)=O
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (494.44 mM), when pH is adjusted to 2-3 with HCl.

DMSO: 26.25 mg/mL (129.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.9444 mL	24.7219 mL	49.4438 mL	247.2188 mL
5 mM	0.9889 mL	4.9444 mL	9.8888 mL	49.4438 mL
10 mM	0.4944 mL	2.4722 mL	4.9444 mL	24.7219 mL
20 mM	0.2472 mL	1.2361 mL	2.4722 mL	12.3609 mL
50 mM	0.0989 mL	0.4944 mL	0.9889 mL	4.9444 mL
100 mM	0.0494 mL	0.2472 mL	0.4944 mL	2.4722 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc