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DS-1971a

Name: DS-1971a
Brand: TargetMol
SKU: T9685
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9685Cas No. 1450595-86-4

DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.

DS-1971a

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Purity: 99.66%

Catalog No. T9685Cas No. 1450595-86-4

DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$61	In Stock	In Stock
2 mg	$88	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$228	In Stock	In Stock
25 mg	$372	In Stock	In Stock
50 mg	$529	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$152	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.66%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.
Targets&IC50	Nav1.7 (mouse):59.4 nM, Nav1.7 (human):22.8 nM
In vitro	DS-1971a showed high NaV1.7 inhibitory potency in vitro. The IC50 values are of 22.8 nM for hNaV1.7 and 59.4 mM for mNaV1.7[1].
In vivo	DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice with ED50 of 0.32 mg/kg[1].

Chemical Properties

Molecular Weight	465.93
Formula	C₂₀H₂₁ClFN₅O₃S
Cas No.	1450595-86-4
Smiles	Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Relative Density.	1.51 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (214.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1462 mL	10.7312 mL	21.4625 mL	107.3123 mL
5 mM	0.4292 mL	2.1462 mL	4.2925 mL	21.4625 mL
10 mM	0.2146 mL	1.0731 mL	2.1462 mL	10.7312 mL
20 mM	0.1073 mL	0.5366 mL	1.0731 mL	5.3656 mL
50 mM	0.0429 mL	0.2146 mL	0.4292 mL	2.1462 mL
100 mM	0.0215 mL	0.1073 mL	0.2146 mL	1.0731 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc