Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mtb-IN-4 (compound 17h) is a non-toxic isoxazole that exhibits anti-Mycobacterium tuberculosis (Mtb) activity, with an IC50 value of 0.70 μM. It impedes Mtb respiration and biofilm formation within macrophages and augments the efficacy of the antibiotic isoniazid (INH) against INH-resistant Mtb mutants [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,520.00 | |
50 mg | 8-10 weeks | $ 1,980.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | Mtb-IN-4 (compound 17h) is a non-toxic isoxazole that exhibits anti-Mycobacterium tuberculosis (Mtb) activity, with an IC50 value of 0.70 μM. It impedes Mtb respiration and biofilm formation within macrophages and augments the efficacy of the antibiotic isoniazid (INH) against INH-resistant Mtb mutants [1]. |
In vitro | Mtb-IN-4 effectively resensitizes Mtb katG mutants to INH inhibition [1]. Additionally, Mtb-IN-4 suppresses the growth of Mtb in mouse RAW 264.7 macrophages with an IC50 of 3.467 μM [1]. |
Molecular Weight | 430.48 |
Formula | C24H18N2O4S |
CAS No. | 2306039-13-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Mtb-IN-4 2306039-13-2 inhibitor inhibit