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Eprodisate disodium

Name: Eprodisate disodium
Brand: TargetMol
SKU: T0382
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0382Cas No. 36589-58-9

Alias NC-503

Eprodisate disodium (NC-503) is a negatively charged sulfonated inhibitor of fibrillogenesis, used in the treatment of amyloid A (AA) amyloidosis.

Eprodisate disodium

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Purity: 99.88%

Catalog No. T0382Alias NC-503Cas No. 36589-58-9

Eprodisate disodium (NC-503) is a negatively charged sulfonated inhibitor of fibrillogenesis, used in the treatment of amyloid A (AA) amyloidosis.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$40	In Stock	In Stock
1 g	$56	-	In Stock
1 mL x 10 mM (in H2O)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Eprodisate disodium AI Summary

Eprodisate disodium has demonstrated multiple bioactivities relevant to both renal disease and antiviral applications. It significantly reduces renal decline in renal disease patients with an activity level of 42.0%. Additionally, it has shown antiviral activity against SARS-CoV-2 by inhibiting the cytotoxicity of Caco-2 cells at a concentration of 10 µM, achieving an inhibition rate of 7.32% after 48 hours. Furthermore, it exhibits a 10.28% inhibition of SARS-CoV-2 3CL-Pro protease activity at a concentration of 20 µM, which is vital for the virus's replication and survival. It also inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells under similar conditions, with an observed inhibition percentage of 0.08% after 48 hours of exposure..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Eprodisate disodium (NC-503) is a negatively charged sulfonated inhibitor of fibrillogenesis, used in the treatment of amyloid A (AA) amyloidosis.
Synonyms	NC-503

Chemical Properties

Molecular Weight	248.19
Formula	C₃H₆Na₂O₆S₂
Cas No.	36589-58-9
Smiles	[Na+].[O-]S(=O)(=O)CCCS(=O)(=O)[O-].[Na+]
Relative Density.	1.773 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Insoluble

H2O: 10 mM, Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.0292 mL	20.1459 mL	40.2917 mL	201.4586 mL
5 mM	0.8058 mL	4.0292 mL	8.0583 mL	40.2917 mL
10 mM	0.4029 mL	2.0146 mL	4.0292 mL	20.1459 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc