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Ajmaline

Name: Ajmaline
Brand: TargetMol
SKU: T4550
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4550Cas No. 4360-12-7

Alias Tachmalin, Raugalline, Cardiorythmine, (+)-Ajmaline

Ajmaline (Cardiorythmine) is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and Kv4.3 channels at therapeutic concentrations.

Ajmaline

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Purity: 99.87%

Catalog No. T4550Alias Tachmalin, Raugalline, Cardiorythmine, (+)-AjmalineCas No. 4360-12-7

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$40	In Stock	In Stock
500 mg	$92	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Ajmaline AI Summary

Ajmaline is a potential inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 1137.4 nM in cell assays, specifically in the presence of CPT..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ajmaline (Cardiorythmine) is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and Kv4.3 channels at therapeutic concentrations.
Synonyms	Tachmalin, Raugalline, Cardiorythmine, (+)-Ajmaline

Chemical Properties

Molecular Weight	326.44
Formula	C₂₀H₂₆N₂O₂
Cas No.	4360-12-7
Smiles	[H][C@]12C3CC4C5C(O)[C@]1(C[C@@H]5N3[C@]([H])(O)[C@@]4([H])CC)C1=C(C=CC=C1)N2C
Relative Density.	1.1117 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40.00 mg/mL (122.53 mM), Sonication is recommended.

Chloroform: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (6.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0634 mL	15.3168 mL	30.6335 mL	153.1675 mL
5 mM	0.6127 mL	3.0634 mL	6.1267 mL	30.6335 mL
10 mM	0.3063 mL	1.5317 mL	3.0634 mL	15.3168 mL
20 mM	0.1532 mL	0.7658 mL	1.5317 mL	7.6584 mL
50 mM	0.0613 mL	0.3063 mL	0.6127 mL	3.0634 mL
100 mM	0.0306 mL	0.1532 mL	0.3063 mL	1.5317 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc