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Abafungin
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Catalog No. T21448Cas No. 129639-79-8
Alias UNII-11DI31LWXF, Bay w 6341
Abafungin (Bay w 6341) is an antifungal agent with a broad-spectrum.
Abafungin
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Purity: 98.11%
Catalog No. T21448Alias UNII-11DI31LWXF, Bay w 6341Cas No. 129639-79-8
Abafungin (Bay w 6341) is an antifungal agent with a broad-spectrum.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $38 | In Stock | In Stock | |
| 10 mg | $65 | In Stock | In Stock | |
| 25 mg | $110 | In Stock | In Stock | |
| 50 mg | $163 | In Stock | In Stock | |
| 100 mg | $238 | In Stock | In Stock | |
| 200 mg | $353 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.11%
Appearance:Solid
Color:White
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Product Introduction
Abafungin AI Summary
Abafungin exhibits significant antiviral and antifungal activities. It shows potent inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 μM concentration with an inhibition rate of 92.89% after 48 hours, and a lesser inhibition rate of -0.22% in VERO-6 cells under similar conditions. The compound also moderately inhibits the SARS-CoV-2 3CL-Pro protease with 9.394% inhibition at 20 μM, observed through a FRET assay.
For antifungal properties, Abafungin demonstrates activity against Candida albicans with a MIC of 312.5 nM and against Aspergillus fumigatus ATCC 204305 with a MIC value of 2.0 μg/mL. It also shows efficacy against pan-azole resistant Aspergillus fumigatus SR47013 with similar MIC values. However, it does not exhibit antifungal activity against Cryptococcus neoformans, nor does it show antibacterial activity as evidenced by MIC values greater than 20000.0 nM against several bacterial strains.
In addition, Abafungin exhibits inhibition of human HDAC6 activity, with 38.23% inhibition using a commercial peptide substrate. It has low hemolytic activity on human red blood cells (HC10 > 20.0 μM) and no cytotoxicity against HEK293 cells (CC50 > 20000.0 nM). The compound shows metabolic stability in human liver microsomes (64.0%) but much lower stability in rat liver microsomes at 0.5 μM. Pharmacokinetic data indicate an unbound fraction of less than 0.001 in Sprague-Dawley rats, a clearance rate of 51.4 mL.min-1.kg-1, and a volume of distribution at steady state of 4.92 L.kg-1..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Abafungin (Bay w 6341) is an antifungal agent with a broad-spectrum. |
| Synonyms | UNII-11DI31LWXF, Bay w 6341 |
| Molecular Weight | 378.49 |
| Formula | C21H22N4OS |
| Cas No. | 129639-79-8 |
| Smiles | Cc1ccc(Oc2ccccc2-c2csc(NC3=NCCCN3)n2)c(C)c1 |
| Relative Density. | 1.28g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 38.3 mg/mL (101.19 mM), Sonication is recommended.  H2O: Insoluble | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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