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Anti-RGS2 Polyclonal Antibody
😃Good
Catalog No. TMAB-12227
Anti-RGS2 Polyclonal Antibody is a Rabbit antibody targeting RGS2. Anti-RGS2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-RGS2 Polyclonal Antibody
Anti-RGS2 Polyclonal Antibody
😃Good
Catalog No. TMAB-12227
Anti-RGS2 Polyclonal Antibody is a Rabbit antibody targeting RGS2. Anti-RGS2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-RGS2 Polyclonal Antibody is a Rabbit antibody targeting RGS2. Anti-RGS2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Rat (predicted:Mouse,Chicken,Pig,Cow,Horse,Sheep) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus. Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus. Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus. Isoform 4: Cell membrane. Mitochondrion. |
| Tissue Specificity | Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL). |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq]. |
| Immunogen | KLH conjugated synthetic peptide: human RGS2 |
| Antigen Species | Human |
| Gene Name | RGS2 |
| Gene ID | |
| Protein Name | Regulator of G-protein signaling 2 |
| Uniprot ID | |
| Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. |
| Molecular Weight | Theoretical: 24 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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