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KRAS G12C inhibitor 19

Name: KRAS G12C inhibitor 19
Brand: TargetMol
SKU: T40286
Price: 83 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40286Cas No. 2649788-46-3

KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that demonstrates anti-tumor activity in cellular assays and inhibits tumor growth [1].

KRAS G12C inhibitor 19

🥰Excellent

Purity: 97.46%

Catalog No. T40286Cas No. 2649788-46-3

KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that demonstrates anti-tumor activity in cellular assays and inhibits tumor growth [1].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$83	In Stock	In Stock
5 mg	$196	In Stock	In Stock
10 mg	$295	In Stock	In Stock
25 mg	$572	In Stock	In Stock
50 mg	$818	In Stock	In Stock
100 mg	$1,130	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:97.46%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that demonstrates anti-tumor activity in cellular assays and inhibits tumor growth [1].

Chemical Properties

Molecular Weight	528.96
Formula	C₂₅H₁₉ClF₂N₄O₃S
Cas No.	2649788-46-3
Smiles	C(#N)C=1C2=C(C=CC(F)=C2SC1N)C=3C(Cl)=C4C(=CC3F)C(=O)N5[C@@](CCO4)(CN(C(C=C)=O)CC5)[H]

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 52.90 mg/mL (100 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (18.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8905 mL	9.4525 mL	18.9050 mL	94.5251 mL
5 mM	0.3781 mL	1.8905 mL	3.7810 mL	18.9050 mL
10 mM	0.1891 mL	0.9453 mL	1.8905 mL	9.4525 mL
20 mM	0.0945 mL	0.4726 mL	0.9453 mL	4.7263 mL
50 mM	0.0378 mL	0.1891 mL	0.3781 mL	1.8905 mL
100 mM	0.0189 mL	0.0945 mL	0.1891 mL	0.9453 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc