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Diosgenin glucoside

Name: Diosgenin glucoside
Brand: TargetMol
SKU: T3874
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3874Cas No. 14144-06-0

Alias Trillin, Disogluside

Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis. Significant inhibition of Diosgenin glucoside synthesis and stimulation of solasodine glucosylation was found only with PC molecular species containing fatty acids with a chain length of 12-18 carbon atoms.

Diosgenin glucoside

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Purity: 99.44%

Catalog No. T3874Alias Trillin, DisoglusideCas No. 14144-06-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$55	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$185	In Stock	In Stock
50 mg	$276	In Stock	In Stock
100 mg	$397	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.44%

Color:White

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Product Introduction

Diosgenin glucoside AI Summary

Diosgenin glucoside shows cytotoxicity against human erythrocytes, with a hemolytic dose for 50% of the cells (HD50) being greater than 100.0 uM after 60 minutes. It demonstrates antidiabetic activity in streptozotocin-induced diabetic ICR mice, where at a 10 mg/kg dosage, it results in decreased body weight and increased blood glucose levels after both 1 week and 9 weeks of administration. At a 20 mg/kg dosage, it has less effect on body weight but still increases blood glucose levels after both 1 week and 9 weeks. Additionally, Diosgenin glucoside shows a high binding affinity to IL-2 with a Kd value of 0.0289 nM, suggesting potential anti-inflammatory properties. It also exhibits anticancer activity against human HepG2 cells with an IC50 value of 30300.0 nM after 24 hours, indicating potential cytotoxic effects on cancer cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis. Significant inhibition of Diosgenin glucoside synthesis and stimulation of solasodine glucosylation was found only with PC molecular species containing fatty acids with a chain length of 12-18 carbon atoms.
Synonyms	Trillin, Disogluside

Chemical Properties

Molecular Weight	576.76
Formula	C₃₃H₅₂O₈
Cas No.	14144-06-0
Smiles	[H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]1(CC[C@@H](C)CO1)O2)O[C@]1([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 7.79 mg/mL (13.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (4.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7338 mL	8.6691 mL	17.3382 mL	86.6912 mL
5 mM	0.3468 mL	1.7338 mL	3.4676 mL	17.3382 mL
10 mM	0.1734 mL	0.8669 mL	1.7338 mL	8.6691 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc