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N-Methylflindersine

🥰Excellent
Catalog No. TN4614Cas No. 50333-13-6
Alias 2,2,6-trimethylpyrano[3,2-c]quinolin-5-one, 2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one

N-Methylflindersine (2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one) shows strong toxicity towards brine shrimp larvae, with an LD(50) value of 1.39 microg/ml. It also exhibits potent inhibition against N -formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM.

N-Methylflindersine

N-Methylflindersine

🥰Excellent
Purity: 98.73%
Catalog No. TN4614Alias 2,2,6-trimethylpyrano[3,2-c]quinolin-5-one, 2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-oneCas No. 50333-13-6
N-Methylflindersine (2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one) shows strong toxicity towards brine shrimp larvae, with an LD(50) value of 1.39 microg/ml. It also exhibits potent inhibition against N -formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM.
Pack SizePriceAvailabilityQuantity
1 mg$89In Stock
5 mg$272In Stock
10 mg$396In Stock
25 mg$663In Stock
50 mg$927In Stock
1 mL x 10 mM (in DMSO)$238In Stock
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Purity:98.73%
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Product Introduction

Bioactivity
Description
N-Methylflindersine (2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one) shows strong toxicity towards brine shrimp larvae, with an LD(50) value of 1.39 microg/ml. It also exhibits potent inhibition against N -formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM.
In vitro
Among the isolates, N-methylflindersine , (-)-simulanol , and evofolin-C exhibited potent inhibition against N-formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM[2].
Synonyms2,2,6-trimethylpyrano[3,2-c]quinolin-5-one, 2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one
Chemical Properties
Molecular Weight241.29
FormulaC15H15NO2
Cas No.50333-13-6
SmilesCn1c2ccccc2c2OC(C)(C)C=Cc2c1=O
Relative Density.1.22g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (248.66 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.1444 mL20.7220 mL41.4439 mL207.2195 mL
5 mM0.8289 mL4.1444 mL8.2888 mL41.4439 mL
10 mM0.4144 mL2.0722 mL4.1444 mL20.7220 mL
20 mM0.2072 mL1.0361 mL2.0722 mL10.3610 mL
50 mM0.0829 mL0.4144 mL0.8289 mL4.1444 mL
100 mM0.0414 mL0.2072 mL0.4144 mL2.0722 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

N-MethylflindersineNMethylflindersineN MethylflindersineInhibitorinhibit
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