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TargetMol | Compound Library

Mitochondria-Targeted Compound Library

Catalog No. L5300

The mitochondrion is a double-membrane-bound discrete organelle found in most eukaryotic organisms, generating most of the cell's supply of adenosine triphosphate (ATP) and controlling the cellular basal metabolic rate, called as the cell's powerhouses. In addition to supplying cellular energy, mitochondria are the major source of ROS (reactive oxygen species) that reflect the level of cellular oxidative stress and play an important role in mitochondria ROS signaling such as apoptosis, proliferation, and aging, etc. In addition, the fine modulation of mitochondrial calcium (Ca2+) homeostasis plays a fundamental role in many of the processes involving this organelle. Mitochondrial Ca2+ accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. Mitochondrial DNA mutations may lead to many mitochondrial metabolic disorders, and are thought to contribute to aging by promoting apoptosis. Mitochondria therefore represent an attractive drug target for metabolic diseases, neurodegeneration, or hyperproliferative diseases (cancer). A number of pre-clinical and clinical data have shown that mitochondria as drug targets have great potential. Small molecule drugs or biologics can act on mitochondria through various pathways including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca2+ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation. Mitochondria-Targeted Compound Library from TargetMol, a unique collection of 950 compounds targeting mitochondria, can be used for research in mitochondrial medicine and related target study.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L5300

Mitochondria-Targeted Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Product Description Product Description

  • A unique collection of 950 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine;
  • Targets include mitochondria related targets, such as ATPase, mitochondria-associated hexokinase, Bcl-2, NADP, etc. and inhibitors for the autophagy initiating factor, ULK1, also include other promising mitochondria-targeted compounds such as lonidamine, paclitaxel, etc;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

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Library Customization | TargetMol Library Composition

Apoptosis
Reactive Oxygen Species
Autophagy
Src
Endogenous Metabolite
AMPK
MAO
Bcl-2 Family
Monoamine Oxidase
Mitochondrial Metabolism
Antibacterial
Dehydrogenase
Mitophagy
ROS
PPAR
Sirtuin
Parasite
Cannabinoid Receptor
NADPH
DNA/RNA Synthesis
Antifungal
VEGFR
NF-κB
Antibiotic
Caspase
Bcr-Abl
COX
Antioxidant
Akt
HIV Protease
Ferroptosis
Cytochromes P450
PDGFR
Influenza Virus
FGFR
p38 MAPK
EGFR
Nrf2
FLT
Calcium Channel
c-Kit
ROS Kinase
PI3K
JAK
PDK
Potassium Channel
NADPH-oxidase
mTOR
OXPHOS
TNF
ATPase
Topoisomerase
CDK
Microtubule Associated
Virus Protease
PARP
ERK
IL Receptor
MMP
Aurora Kinase
HDAC
HIF/HIF Prolyl-Hydroxylase
NO Synthase
c-Met/HGFR
Adrenergic Receptor
Raf
HSV
Cholinesterase (ChE)
IGF-1R
5-HT Receptor
c-RET
MDM-2/p53
p53
Estrogen/progestogen Receptor
JNK
Phosphatase
PKC
SARS-CoV
ALK
GABA Receptor
Sodium Channel
GSK-3
Wnt/beta-catenin
TRP/TRPV Channel
PTEN
Xanthine Oxidase
Interleukin
IκB/IKK
STAT
MEK
AChR
Anti-infection
FAK
NOS
Histone Demethylase
PKA
VDAC
Lipoxygenase
Beta Amyloid
Phospholipase
Ras
S6 Kinase
Tyrosinase
Bcl-6
Estrogen Receptor/ERR
Tyrosine Kinases
Glucosidase
Hexokinase
DUB
TGF-beta/Smad
HSP
Prostaglandin Receptor
TLR
Trk receptor
Casein Kinase
c-Fms
Syk
Chloride channel
Carbonic Anhydrase
Transferase
Dynamin
Ligands for Target Protein for PROTAC
DYRK
RAAS
HBV
Hck
Cysteine Protease
IAP
Gamma-secretase
Opioid Receptor
Fatty Acid Synthase
Chk
Epigenetic Reader Domain
CaMK
Androgen Receptor
Beta-Secretase
MAPK
Acyltransferase
P-gp
Antiviral
Ephrin Receptor
Reverse Transcriptase
Complement System
HMG-CoA Reductase
NOD-like Receptor (NLR)
Imidazoline Receptor
ADC Cytotoxin
Proteasome
Mdm2
Monocarboxylate transporter
Dopamine Receptor
ROR
Integrin
Adenosine Receptor
Arrestin
BACE
Histamine Receptor
Serine/threonin kinase
Nucleoside Antimetabolite/Analog
ROCK
Glucocorticoid Receptor
CSF-1R
Immunology/Inflammation related
iGluR
Prolyl Endopeptidase (PREP)
IRE1
E1/E2/E3 Enzyme
UGT
LDL
Drug Metabolite
Glucagon Receptor
NMDAR
Guanylate cyclase
Angiotensin-converting Enzyme (ACE)
cAMP
DNA
STING
LRRK2
Free radical scavengers
transporter
Hydroxylase
HIF
AhR
CFTR
MLK
GPCR
CAT
NPC1L1
Hydrogenase
RAR/RXR
Histone Methyltransferase
HCV Protease
MyD88
YAP
Reductase
Na+/Ca2+ Exchanger
IFNAR
Aconitase
PERK
Necroptosis
gp120/CD4
Tie-2
Glutathione Peroxidase
Melatonin Receptor
c-Myc
CaSR
MRP
Rho
Serine Protease
Serotonin Transporter
FXR
Glucokinase
PYK2
IDO
SIK
Annexin A
Photosystem (PS)
P2X Receptor
ABC Transporter
Na-K-Cl cotransporter
BTK
Antifection
Monoamine Transporter
Molecular Glues
Hedgehog/Smoothened
DNA Alkylation
PAK
FAAH
ACK1
Somatostatin
GluR
Indoleamine 2,3-Dioxygenase (IDO)
SGLT
ATP Citrate Lyase
Lipid
Glutathione reductase
Aminopeptidase
Histone Acetyltransferase
CPT
GluCls
Pyroptosis
RSV
Methionine Adenosyltransferase (MAT)
ATM/ATR
p62
Retinoid Receptor
Kras
Aromatase
CRISPR/Cas9
Cuproptosis
SGK
Discoidin Domain Receptor (DDR)
Gap Junction Protein
Platelet aggregation
BMI-1
NOD
IRAK
TAM Receptor
Thrombin
p97

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