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TargetMol | Compound Library

Mitochondria-Targeted Compound Library

Catalog No. L5300

The mitochondrion is a double-membrane-bound discrete organelle found in most eukaryotic organisms, generating most of the cell's supply of adenosine triphosphate (ATP) and controlling the cellular basal metabolic rate, called as the cell's powerhouses. In addition to supplying cellular energy, mitochondria are the major source of ROS (reactive oxygen species) that reflect the level of cellular oxidative stress and play an important role in mitochondria ROS signaling such as apoptosis, proliferation, and aging, etc. In addition, the fine modulation of mitochondrial calcium (Ca2+) homeostasis plays a fundamental role in many of the processes involving this organelle. Mitochondrial Ca2+ accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. Mitochondrial DNA mutations may lead to many mitochondrial metabolic disorders, and are thought to contribute to aging by promoting apoptosis. Mitochondria therefore represent an attractive drug target for metabolic diseases, neurodegeneration, or hyperproliferative diseases (cancer). A number of pre-clinical and clinical data have shown that mitochondria as drug targets have great potential. Small molecule drugs or biologics can act on mitochondria through various pathways including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca2+ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation. Mitochondria-Targeted Compound Library from TargetMol, a unique collection of 950 compounds targeting mitochondria, can be used for research in mitochondrial medicine and related target study.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L5300

Mitochondria-Targeted Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Product Description Product Description

  • A unique collection of 950 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine;
  • Targets include mitochondria related targets, such as ATPase, mitochondria-associated hexokinase, Bcl-2, NADP, etc. and inhibitors for the autophagy initiating factor, ULK1, also include other promising mitochondria-targeted compounds such as lonidamine, paclitaxel, etc;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

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Reactive Oxygen Species
Apoptosis
Autophagy
Src
AMPK
MAO
Endogenous Metabolite
Bcl-2 Family
Mitochondrial Metabolism
ROS
Mitophagy
Dehydrogenase
Antibacterial
Monoamine Oxidase
PPAR
Sirtuin
Cannabinoid Receptor
NADPH
NF-κB
Parasite
COX
VEGFR
Antibiotic
Antifungal
Bcr-Abl
Antioxidant
Caspase
Cytochromes P450
HIV Protease
Ferroptosis
Akt
FGFR
PDGFR
FLT
c-Kit
p38 MAPK
EGFR
Influenza Virus
DNA/RNA Synthesis
JAK
NADPH-oxidase
PDK
ATPase
Potassium Channel
ROS Kinase
Calcium Channel
IL Receptor
mTOR
NO Synthase
Nrf2
PI3K
TNF
Topoisomerase
Aurora Kinase
CDK
Microtubule Associated
MMP
PARP
5-HT Receptor
c-Met/HGFR
HDAC
HIF/HIF Prolyl-Hydroxylase
HSV
p53
Virus Protease
Adrenergic Receptor
ALK
Cholinesterase (ChE)
ERK
Estrogen/progestogen Receptor
IGF-1R
PKC
Raf
STAT
c-RET
GSK-3
JNK
MEK
Sodium Channel
AChR
Beta Amyloid
FAK
GABA Receptor
Histone Demethylase
IκB/IKK
NOS
PKA
SARS-CoV
Tyrosinase
Wnt/beta-catenin
Xanthine Oxidase
c-Fms
DUB
Hexokinase
HSP
Lipoxygenase
P-gp
Phospholipase
S6 Kinase
Syk
Trk receptor
Tyrosine Kinases
VDAC
Acyltransferase
Anti-infection
Antiviral
CaMK
Carbonic Anhydrase
Casein Kinase
Chk
Cysteine Protease
Dynamin
DYRK
Ephrin Receptor
Epigenetic Reader Domain
Estrogen Receptor/ERR
Fatty Acid Synthase
Gamma-secretase
HBV
Hck
HMG-CoA Reductase
IAP
Imidazoline Receptor
MAPK
OXPHOS
Phosphatase
Prostaglandin Receptor
RAAS
Reverse Transcriptase
TGF-beta/Smad
TLR
Transferase
TRP/TRPV Channel
ADC Cytotoxin
Adenosine Receptor
AhR
Androgen Receptor
ATP Citrate Lyase
BACE
cAMP
CFTR
Chloride channel
Complement System
CSF-1R
DNA
Dopamine Receptor
E1/E2/E3 Enzyme
Free radical scavengers
Glucagon Receptor
Glucocorticoid Receptor
Guanylate cyclase
HIF
Histamine Receptor
Immunology/Inflammation related
Integrin
IRE1
LDL
Ligands for Target Protein for PROTAC
LRRK2
Mdm2
MLK
Monocarboxylate transporter
NMDAR
Nucleoside Antimetabolite/Analog
Opioid Receptor
Proteasome
ROCK
ROR
Serine Protease
transporter
UGT
ABC Transporter
ACK1
Aconitase
Aminopeptidase
Annexin A
Antifection
Aromatase
Arrestin
ATM/ATR
Beta-Secretase
BMI-1
BTK
CaSR
CPT
CRISPR/Cas9
Discoidin Domain Receptor (DDR)
DNA Alkylation
FAAH
Gap Junction Protein
GluCls
Glucokinase
GluR
Glutathione Peroxidase
Glutathione reductase
gp120/CD4
GPCR
HCV Protease
Hedgehog/Smoothened
Histone Acetyltransferase
Histone Methyltransferase
Hydrogenase
Hydroxylase
IFNAR
Interleukin
IRAK
Lipid
Melatonin Receptor
Monoamine Transporter
MRP
MyD88
Na+/Ca2+ Exchanger
NOD
NOD-like Receptor (NLR)
NPC1L1
P2X Receptor
p97
PERK
Platelet aggregation
PTEN
RAR/RXR
Ras
Retinoid Receptor
Rho
RSV
Serine/threonin kinase
Serotonin Transporter
SGK
SGLT
SIK
Somatostatin
STING
TAM Receptor
Thrombin
Tie-2
YAP

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