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Anti-BTC Antibody (7D630)
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Catalog No. TMAB-03244 Copy Product Info
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Anti-BTC Antibody (7D630) is a Mouse antibody targeting BTC. Anti-BTC Antibody (7D630) can be used in WB,ICC/IF.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 µL | $148 | 7-10 days | 7-10 days | |
| 50 µL | $261 | 7-10 days | 7-10 days | |
| 100 µL | $472 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Stability & Storage
| Description | Anti-BTC Antibody (7D630) is a Mouse antibody targeting BTC. Anti-BTC Antibody (7D630) can be used in WB,ICC/IF. |
| Ig Type | IgG1, Kappa |
| Clone | 7D630 |
| Reactivity | Human |
| Verified Activity | 1. Cell line: PC-3 Fixative: 4% Paraformaldehyde Permeabilization: 0.1% TritonX-100 Primary ab dilution: 1:50 Primary incubation condition: 4°C overnight Secondary ab: Goat Anti-Mouse IgG Nuclear counter stain: DAPI (Blue) Comment: Color green is the positive signal for TMAB-03244 2. Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: room temperature 2 h Secondary ab: Goat Anti-Mouse IgG H&L (HRP) Lysate: Panc-1, PC-3, T47D Protein loading quantity: 20 μg Exposure time: 30 s Predicted MW: 20 kDa Observed MW: 20 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cell membrane and Secreted > extracellular space. |
| Tissue Specificity | Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine. |
| Construction | Recombinant Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Betacellulin (BTC), a member of the epidermal growth factor (EGF) family, was originally identified as a growth-promoting factor in the conditioned medium of a mouse pancreatic-cell carcinoma (insulinoma) cell line and has since been identified in humans. BTC is synthesized as a large transmembrane precursor molecule that can be cleaved proteolytically to release the soluble form of BTC or function as membrane-anchored growth factors in juxtacrine signaling. BTC, in addition to stimulating homodimers of ErbB-1 and ErbB-4, is capable of binding and activating all possible combinations of heterodimeric ErbB receptors including the oncogenic ErbB-2/ErbB-3 complex. BTC is also expressed in some human malignancies and may have an important role in tumor growth progression. |
| Gene Name | BTC |
| Gene ID | |
| Protein Name | Probetacellulin |
| Function | Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. The effects of betacellulin are probably mediated by the EGF receptor and other related receptors. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Anti-BTC Antibody (7D630) chemical structure
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