Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8]
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 μg | 35 days | $ 538.00 | |
1 mg | 35 days | $ 860.00 |
Description | Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8] |
In vitro | In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with isoproterenol , and treatment with this metabolite at 100 μM under heat stress conditions induces the release of oxytocin from the mouse hypothalamus.[9],[4] |
Synonyms | cADP-Ribose, cADPR, Cyclic ADP-Ribose (ammonium salt) |
Molecular Weight | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Soluble
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Cyclic ADP-Ribose (ammonium salt) cADP-Ribose Cyclic ADP-Ribose Cyclic ADP Ribose (ammonium salt) Cyclic ADPRibose (ammonium salt) cADPR inhibitor inhibit