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Cyclic ADP-Ribose (ammonium salt)

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Catalog No. T37475
Alias Cyclic ADP-Ribose (ammonium salt), cADP-Ribose, cADPR

Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8]

Cyclic ADP-Ribose (ammonium salt)
Other Forms of Cyclic ADP-Ribose (ammonium salt):
Cyclic ADP-riboseT19253119340-53-3
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Cyclic ADP-Ribose (ammonium salt)

😃Good
Catalog No. T37475Alias Cyclic ADP-Ribose (ammonium salt), cADP-Ribose, cADPR
Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8]
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500 μg$53835 days
1 mg$86035 days
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Bioactivity
Description
Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8]
In vitro
In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with isoproterenol , and treatment with this metabolite at 100 μM under heat stress conditions induces the release of oxytocin from the mouse hypothalamus.[9],[4]
SynonymsCyclic ADP-Ribose (ammonium salt), cADP-Ribose, cADPR
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: Soluble

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Keywords

Cyclic ADP-RiboseCyclic ADP Ribose (ammonium salt)Cyclic ADPRibose (ammonium salt)
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