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3'-Methoxyflavonol

Name: 3'-Methoxyflavonol
Brand: TargetMol
SKU: T8035
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8035Cas No. 76666-32-5

3'-Methoxyflavonol is a potent, selective agonist of neuromedin U 2 receptor (NMU2R).

3'-Methoxyflavonol

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Purity: 99.32%

Catalog No. T8035Cas No. 76666-32-5

3'-Methoxyflavonol is a potent, selective agonist of neuromedin U 2 receptor (NMU2R).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$31	In Stock	In Stock
50 mg	$41	In Stock	In Stock
100 mg	$56	In Stock	In Stock
200 mg	$80	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.32%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

3'-Methoxyflavonol AI Summary

3'-Methoxyflavonol exhibits a diverse range of bioactivities. It has shown vasorelaxant activity in Sprague-Dawley rat thoracic aorta under both endothelium-dependent and endothelium-independent conditions, with various EC50 values indicating its potency. Additionally, it demonstrates antioxidant properties by reducing superoxide levels and DPPH scavenging activities within the same experimental model. 3'-Methoxyflavonol is also potent as an inhibitor in various biochemical assays, targeting interactions such as Menin-MLL, human Jumonji Domain-containing 2E (JMJD2E), and Thyroid Stimulating Hormone Receptor, among others. It inhibits multiple enzymes including Tyrosyl-DNA Phosphodiesterase (TDP1), Cytochrome P450 isoforms (2C19, 2D6, 2C9, 3A4), 12-human lipoxygenase (12-hLO), and 15-Hydroxyprostaglandin Dehydrogenase (HPGD), and modulates cellular functions like ERK signaling pathway and Tau fibril formation. Furthermore, it shows antiviral properties against Lassa Virus and Marburg Virus, and anti-parasitic activity against Trypanosoma brucei brucei Lister 427, with an EC50 of 2320.0 nM and a selectivity index of 4.0. In prostate cancer models, it inhibits prostate-specific antigen (PSA) and androgen receptor (AR) expression in human 22Rv1 cells, showing antiproliferative activity with an IC50 of 5300.0 nM. Moreover, it exhibits cytotoxic activity against human HCT116 cells, with notable viability reduction at 15 uM after 48 hours. Overall, 3'-Methoxyflavonol demonstrates significant potential due to its broad bioactivity spectrum including vascular, antioxidant, enzymatic inhibition, antiviral, antiproliferative, and antitrypanosomal properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

3'-Methoxyflavonol is a potent, selective agonist of neuromedin U 2 receptor (NMU2R).

Chemical Properties

Molecular Weight	268.26
Formula	C₁₆H₁₂O₄
Cas No.	76666-32-5
Smiles	COc1cccc(c1)-c1oc2ccccc2c(=O)c1O
Relative Density.	1.353g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 155 mg/mL (577.8 mM), Heating is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (12.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7277 mL	18.6386 mL	37.2773 mL	186.3863 mL
5 mM	0.7455 mL	3.7277 mL	7.4555 mL	37.2773 mL
10 mM	0.3728 mL	1.8639 mL	3.7277 mL	18.6386 mL
20 mM	0.1864 mL	0.9319 mL	1.8639 mL	9.3193 mL
50 mM	0.0746 mL	0.3728 mL	0.7455 mL	3.7277 mL
100 mM	0.0373 mL	0.1864 mL	0.3728 mL	1.8639 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc