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ISOGINKGETIN

Catalog No. T4S21320 CAS 548-19-6

Synonyms: 4',4'''-Dimethylamentoflavone

1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponectin production. 2. Isoginkgetin has anti-tumor activity, the mechanistic basis is splicing inhibition , thus, pre-mRNA splicing inhibitors may represent a novel avenue for development of new anti-cancer agents.3. Isoginkgetin can inhibit tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. 4. Isoginkgetin (0.3mg/kg ip for 3d) can reduce the level of O2·- in plasma and erythroeyte and sometimes increase the activity of SOD in anoxic rats, the action being stronger than aspirin.

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ISOGINKGETIN, CAS 548-19-6

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5 mg	In stock	$ 48.00

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Purity: 99.72%

Purity: 99.41%

Purity: 99.31%

Purity: 98.9%

Purity: 98.25%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Source

Natural Products > Ginkgoaceae > Ginkgo

Synonyms	4',4'''-Dimethylamentoflavone
Molecular Weight	566.51
Formula	C32H22O10
CAS No.	548-19-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.3 mg/mL (147.04 mM)

References and Literature

1. Suhua P . Effect of Isoginkgetin on Scavenge of Oxygen Free Radical in Anoxic Rats[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 1993.

Citations

1. Theerawatanasirikul S, Thangthamniyom N, Kuo C J, et al. Natural Phytochemicals, Luteolin and Isoginkgetin, Inhibit 3C Protease and Infection of FMDV, In Silico and In Vitro. Viruses. 2021, 13(11): 2118. 2. Xiao Y, Cai G P, Feng X, et al.Splicing factor YBX1 regulates bone marrow stromal cell fate during aging.The EMBO Journal.2023: e111762.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Natural Product Library for HTS Inhibitor Library Flavonoid Natural Product Library Traditional Chinese Medicine Monomer Library Natural Product Library Food as Medicine Compound Library Selected Plant-Sourced Compound Library Bioactive Compound Library Anti-Cancer Compound Library

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Keywords

ISOGINKGETIN 548-19-6 Others Proteases/Proteasome MMP inhibit NF-κB Matrix metalloproteinases Inhibitor HeLa HT1080 Proteasome Nuclear factor-κB Autophagy Nuclear factor-kappaB Apoptosis Protein kinase B 4',4'''-Dimethylamentoflavone Akt anticancer PKB inhibitor

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