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Neoandrographolide

Name: Neoandrographolide
Brand: TargetMol
SKU: T3884
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3884Cas No. 27215-14-1

Alias Neoandrographiside

Neoandrographolide (Neoandrographiside) has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has anti-inflammatory effect, might result from inhibition of iNOS and COX-2 expression through inhibiting p38 MAPKs activation.Neoandrographolide as chemosensitizer in S-Jurkat and X chromosome-linked inhibitor of apoptosis protein (XIAP)-overexpressing Jurkat cells, a model for chemoresistance.

Neoandrographolide

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Purity: 99.67%

Catalog No. T3884Alias NeoandrographisideCas No. 27215-14-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$81	In Stock	In Stock
10 mg	$129	In Stock	In Stock
25 mg	$263	In Stock	In Stock
50 mg	$423	In Stock	In Stock
100 mg	$679	In Stock	In Stock
200 mg	$945	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.67%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Neoandrographolide AI Summary

Neoandrographolide demonstrates antiproliferative activity against human HL60 cells with a GI50 value of 26670.0 nM. It exhibits immunostimulant activities in sheep RBC-immunized BALB/c albino mice by increasing macrophage migration index and hemagglutinating antibody titer when administered both orally at 1 mg/kg daily for 7 days and intraperitoneally at 4 mg/kg. Additionally, Neoandrographolide induces a significant neurite outgrowth in NGF-induced rat PC12 cells, resulting in a 21.5% increase in neurite-bearing cells at 20 µM concentration when co-treated with 20 ng/ml of NGF over 48 hours. The compound also has a log P value of 3.07, indicating its lipophilicity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Neoandrographiside

Chemical Properties

Molecular Weight	480.59
Formula	C₂₆H₄₀O₈
Cas No.	27215-14-1
Smiles	C[C@@]1(CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)CCC[C@@]2(C)[C@H](CCC3=CCOC3=O)C(=C)CC[C@H]12
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (520.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (20.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0808 mL	10.4039 mL	20.8078 mL	104.0388 mL
5 mM	0.4162 mL	2.0808 mL	4.1616 mL	20.8078 mL
10 mM	0.2081 mL	1.0404 mL	2.0808 mL	10.4039 mL
20 mM	0.1040 mL	0.5202 mL	1.0404 mL	5.2019 mL
50 mM	0.0416 mL	0.2081 mL	0.4162 mL	2.0808 mL
100 mM	0.0208 mL	0.1040 mL	0.2081 mL	1.0404 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc