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Hederagenin

Name: Hederagenin
Brand: TargetMol
SKU: T3039
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3039Cas No. 465-99-6

Alias Hederagenol, Hederagenic acid, Caulosapogenin, Astrantiagenin E

Hederagenin (Hederagenol) is a triterpenoid saponin inhibiting LPS-stimulated expression of iNOS, COX-2, and NF-κB.

Hederagenin

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Purity: 99.11%

Catalog No. T3039Alias Hederagenol, Hederagenic acid, Caulosapogenin, Astrantiagenin ECas No. 465-99-6

Hederagenin (Hederagenol) is a triterpenoid saponin inhibiting LPS-stimulated expression of iNOS, COX-2, and NF-κB.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$81	In Stock	In Stock
50 mg	$123	In Stock	In Stock
100 mg	$179	In Stock	In Stock
500 mg	$453	-	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.11%

Color:White

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Product Introduction

Hederagenin AI Summary

Hederagenin is a multipotent bioactive compound that exhibits a range of biological activities. It shows significant cytotoxicity against various human cell lines, including A549, MDA-MB-231, KB, HeLa, U87MG, HL60, HepG2, MCF7, NCI-H1975, and others, with IC50 values generally ranging from approximately 10,000 nM to over 100,000 nM, depending on the cell line and assay conditions. Additionally, it demonstrates antiparasitic activity against Leishmania infantum with an IC50 of 61,600 nM and a notable selectivity index. The compound also inhibits quinone reductase activity at concentrations >20.0 µg/mL and 5-lipoxygenase (5-LOX) and 15-lipoxygenase (15-LOX2) with IC50 values >40,000 nM, showing residual activity inhibition of up to 64.7%. Hederagenin also has notable antiviral activity, inhibiting HCV pseudo-particles entry in 293T cells, and molluscicidal activity against Pomacea canaliculata without causing toxicity to fish species Oreochromis sp. and Carassius auratus. It exhibits protective effects in hepatoprotective assays against D-GaIN-induced toxicity in HL7702 cells and inhibits LPS-induced tissue factor procoagulant activity in THP1 cells with a low IC50 of 0.221 nM. Furthermore, it shows moderate inhibition of USP7 enzyme activity with an IC50 of 33,500 nM and demonstrates potential in reversing P-glycoprotein mediated drug resistance, enhancing paclitaxel-induced cytotoxicity in KBV cells with an observed activity level of 107.17% at 10 µM. Despite its broad spectrum of bioactivities, Hederagenin demonstrates low toxicity in non-cancerous cells such as DLD1, WS1, and sheep erythrocytes, suggesting a potential therapeutic window for further development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hederagenin (Hederagenol) is a triterpenoid saponin inhibiting LPS-stimulated expression of iNOS, COX-2, and NF-κB.
Synonyms	Hederagenol, Hederagenic acid, Caulosapogenin, Astrantiagenin E

Chemical Properties

Molecular Weight	472.70
Formula	C₃₀H₄₈O₄
Cas No.	465-99-6
Smiles	CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(CO)C5CCC34C)C2C1)C(O)=O
Relative Density.	1.14g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50.00 mg/mL (105.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1155 mL	10.5775 mL	21.1551 mL	105.7753 mL
5 mM	0.4231 mL	2.1155 mL	4.2310 mL	21.1551 mL
10 mM	0.2116 mL	1.0578 mL	2.1155 mL	10.5775 mL
20 mM	0.1058 mL	0.5289 mL	1.0578 mL	5.2888 mL
50 mM	0.0423 mL	0.2116 mL	0.4231 mL	2.1155 mL
100 mM	0.0212 mL	0.1058 mL	0.2116 mL	1.0578 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc