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Anti-HIP55 Polyclonal Antibody
Catalog No. TMAB-07044 Copy Product Info
🥰Excellent
Anti-HIP55 Polyclonal Antibody is a Rabbit antibody targeting HIP55. Anti-HIP55 Polyclonal Antibody can be used in WB.
Anti-HIP55 Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-07044
Anti-HIP55 Polyclonal Antibody is a Rabbit antibody targeting HIP55. Anti-HIP55 Polyclonal Antibody can be used in WB.
Anti-HIP55 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
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| Description | Anti-HIP55 Polyclonal Antibody is a Rabbit antibody targeting HIP55. Anti-HIP55 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human) |
| Verified Activity | Protein: lymph node (mouse) lyates at 40 μg; spleen (mouse) lyates at 40 μg; Primary: Rabbit Anti-HIP55 (TMAB-07044) at 1:300; Secondary: 800CW Conjugated Goat (polyclonal) Anti-Rabbit Igg (H+L) at 1: 10000; Predicted band size:55 kD Observed band size:55 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=Cortical cytoskeleton. Associates with lamellipodial actin. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| Concentration | 1mg/ml |
| Research Background | Drebrins (developmentally regulated brain proteins) are cytoplasmic proteins that bind F-actin in the brain and are involved in cell migration, extension of neuronal processes and plasticity of dendrites. HIP-55 (HPK1-interacting protein of 55 kDa), also known as ABP1, SH3P7 or DBNL (drebrin-like), is a 430 amino acid cytoplasmic protein that belongs to the ABP1 family. HIP-55 binds to F-actin but is not involved in actin polymerization, capping or bundling. In addition to containing an ADF-H domain, HIP-55 also consists of a SH3 domain, which mediates interaction with SHANK2, SHANK3 and PRAM-1. HIP-55 acts as an actin-binding adapter protein and as a common effector of antigen receptor-signaling pathways in leukocytes. As a key component of the immunological synapse, HIP-55 regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. HIP-55 is degraded by caspases during apoptosis. |
| Immunogen | KLH conjugated synthetic peptide: human HIP55 |
| Antigen Species | Human |
| Gene Name | DBNL |
| Gene ID | |
| Protein Name | Drebrin-like protein |
| Uniprot ID | |
| Function | Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin. |
| Molecular Weight | Theoretical: 55 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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