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Benzocaine hydrochloride

Name: Benzocaine hydrochloride
Brand: TargetMol
SKU: T6782
Rating: 4.5 (1 reviews)

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Catalog No. T6782Cas No. 23239-88-5

Alias Ethyl p-aminobenzoate hydrochloride, Ethyl 4-aminobenzoate hydrochloride, Benzocaine HCl

Benzocaine hydrochloride (Ethyl 4-aminobenzoate hydrochloride) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

Benzocaine hydrochloride

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Catalog No. T6782Alias Ethyl p-aminobenzoate hydrochloride, Ethyl 4-aminobenzoate hydrochloride, Benzocaine HClCas No. 23239-88-5

Benzocaine hydrochloride (Ethyl 4-aminobenzoate hydrochloride) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$50	7-10 days	7-10 days
100 mg	$65	7-10 days	7-10 days
200 mg	$118	7-10 days	7-10 days
500 mg	$198	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$50	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Benzocaine hydrochloride (Ethyl 4-aminobenzoate hydrochloride) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
In vitro	AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and Ki of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. [1] AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM. [2]
Synonyms	Ethyl p-aminobenzoate hydrochloride, Ethyl 4-aminobenzoate hydrochloride, Benzocaine HCl

Chemical Properties

Molecular Weight	201.65
Formula	C₉H₁₁NO₂·HCl
Cas No.	23239-88-5
Smiles	Cl.CCOC(=O)c1ccc(N)cc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 38 mg/mL (188.45 mM), Sonication is recommended.

Ethanol: 38 mg/mL (188.45 mM), Sonication is recommended.

H2O: <1 mg/mL

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	4.9591 mL	24.7954 mL	49.5909 mL	247.9544 mL
5 mM	0.9918 mL	4.9591 mL	9.9182 mL	49.5909 mL
10 mM	0.4959 mL	2.4795 mL	4.9591 mL	24.7954 mL
20 mM	0.2480 mL	1.2398 mL	2.4795 mL	12.3977 mL
50 mM	0.0992 mL	0.4959 mL	0.9918 mL	4.9591 mL
100 mM	0.0496 mL	0.2480 mL	0.4959 mL	2.4795 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc