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LDHA-IN-4
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Catalog No. T3175Cas No. 1370290-34-8
Alias LDHA Inhibitor, AZ-33, AZ33, AZ 33
LDHA-IN-4 (AZ33) is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR analysis with an active value of 0.093 μM.
LDHA-IN-4
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Purity: 99.68%
Catalog No. T3175Alias LDHA Inhibitor, AZ-33, AZ33, AZ 33Cas No. 1370290-34-8
LDHA-IN-4 (AZ33) is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR analysis with an active value of 0.093 μM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $44 | In Stock | In Stock | |
| 5 mg | $97 | In Stock | In Stock | |
| 10 mg | $163 | In Stock | In Stock | |
| 25 mg | $318 | In Stock | In Stock | |
| 50 mg | $478 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.68%
Appearance:Solid
Color:White
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Product Introduction
LDHA-IN-4 AI Summary
LDHA-IN-4 shows binding affinity to 6-His-tagged human LDHA, with a Kd value of 93.0 nM, and inhibits full-length human recombinant LDHA with an IC50 value of 500.0 nM when using sodium pyruvate as a substrate after 10 minutes. In addition to LDHA, LDHA-IN-4 exhibits inhibitory activity against several enzymes involved in cellular metabolism, such as lactate dehydrogenase (LDH) isoforms and malate dehydrogenase (MDH), demonstrating IC50 values ranging from 920.0 nM to over 57,000.0 nM. The compound also shows cytotoxicity against human A673 and MIAPaCa2 cells in long-term inhibition assays with IC50 values greater than 20,000.0 nM. Moreover, it stabilizes LDHA in cellular lysates with an EC50 value of 1600.0 nM, suggesting potential modulation of enzyme activity under certain conditions. These results indicate that LDHA-IN-4 has potential bioactivity and therapeutic implications in targeting LDHA and other metabolic enzymes..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LDHA-IN-4 (AZ33) is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR analysis with an active value of 0.093 μM. |
| Synonyms | LDHA Inhibitor, AZ-33, AZ33, AZ 33 |
| Molecular Weight | 497.56 |
| Formula | C25H27N3O6S |
| Cas No. | 1370290-34-8 |
| Smiles | Cc1nc2ccc(NC(=O)CCNC(=O)CCCc3ccc(CC(C(O)=O)C(O)=O)cc3)cc2s1 |
| Relative Density. | 1.381 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.98 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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