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Baicalin

Name: Baicalin
Brand: TargetMol
SKU: T2775
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2775Cas No. 21967-41-9

Alias Baicalein 7-O-β-D-glucuronide

Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV properties.

Baicalin

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Purity: 99.32%

Catalog No. T2775Alias Baicalein 7-O-β-D-glucuronideCas No. 21967-41-9

Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV properties.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$44	In Stock	In Stock
200 mg	$47	In Stock	In Stock
500 mg	$53	In Stock	In Stock
1 g	$77	In Stock	In Stock
2 g	$109	-	In Stock
5 g	$163	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.32%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Baicalin AI Summary

Baicalin exhibits a diverse range of biological activities. It displays binding affinity to the benzodiazepine site in the GABAA receptor with a Ki value of 77624.71 nM and shows inhibitory activity against bovine testis hyaluronidase with various IC50 values ranging from 450,000.0 nM to 1,600,000.0 nM. It has antiviral activity against HIV1 3B in human H9 cells with an EC50 of 112000.0 nM and demonstrates cytotoxicity with an IC50 of 72000.0 nM. The compound also inhibits trypsin-induced elevation in PAI1 production in HUVEC cells with an IC50 greater than 1,000,000.0 nM and reduces concanavalin A-induced histamine release in Wistar rat peritoneal mast cells with an ID50 of 3.0 x 10^-6 M. Baicalin shows weak displacement of [3H]LSD from the human 5HT7 receptor with an IC50 above 200,000.0 nM, and activity against SARS-CoV-2 3CL-Pro protease by 50.66% at 20 µM. The compound has antibacterial, antifungal, and antiviral activities, including activity against Chikungunya virus and SARS-CoV-2 with varying efficacies. It shows hepatoprotective, anti-inflammatory, cytotoxic, and anti-proliferative properties in different model systems and cell lines. Additionally, Baicalin exhibits activity as an inhibitor of LSD1 with an IC50 of 3010.0 nM and antiproliferative activity against human MGC-803 cells with an IC50 of 8780.0 nM. It affects various biological processes, including cell cycle regulation, enzyme inhibition, and immunomodulation. The compound also has potential for modulating DNA interactions, particularly G4 quadruplex and i-motif structures, and demonstrates permeability across biological barriers..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV properties.
Synonyms	Baicalein 7-O-β-D-glucuronide

Chemical Properties

Molecular Weight	446.36
Formula	C₂₁H₁₈O₁₁
Cas No.	21967-41-9
Smiles	OC1=C2C(OC(=CC2=O)C3=CC=CC=C3)=CC(O[C@@H]4O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]4O)=C1O
Relative Density.	1.737 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 37 mg/mL (82.89 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2403 mL	11.2017 mL	22.4034 mL	112.0172 mL
5 mM	0.4481 mL	2.2403 mL	4.4807 mL	22.4034 mL
10 mM	0.2240 mL	1.1202 mL	2.2403 mL	11.2017 mL
20 mM	0.1120 mL	0.5601 mL	1.1202 mL	5.6009 mL
50 mM	0.0448 mL	0.2240 mL	0.4481 mL	2.2403 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc