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Antimycobacterial agent-4
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Catalog No. T60073Cas No. 476319-66-1
Alias 4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide
Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.
Antimycobacterial agent-4
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Purity: 99.20%
Catalog No. T60073Alias 4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamideCas No. 476319-66-1
Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $36 | - | In Stock | |
| 5 mg | $90 | - | In Stock | |
| 10 mg | $146 | - | In Stock | |
| 25 mg | $243 | - | In Stock | |
| 50 mg | $347 | - | In Stock | |
| 100 mg | $457 | - | In Stock | |
| 200 mg | $622 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.20%
Appearance:Solid
Color:Yellow
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Product Introduction
Antimycobacterial agent-4 AI Summary
Antimycobacterial agent-4 exhibits bioactivities related to adenosine receptors and demonstrates significant pharmacological properties. It has a Ki of 1500.0 nM for displacing [3H]DPCPX binding to the adenosine A1 receptor in rat brain cortical membrane and a 29.0% displacement of [3H]CGS-21680 or [3H]ZM-241,385 binding to the adenosine A2A receptor in rat striatal membrane at 10 µM. Additionally, it shows a Ki of 3500.0 nM for displacing [125I]AB-MECA from the human adenosine A3 receptor expressed in HEK 293 cells. The compound also exhibits potent antimalarial activity with an IC50 of 6100.0 nM against the chloroquine-sensitive asexual erythrocytic stage of Plasmodium falciparum NF54, while displaying low cytotoxicity with an IC50 of 2200.0 nM against CHO cells. Furthermore, Antimycobacterial agent-4 highlights good solubility in PBS buffer with a solubility of 10000.0 nM after 2 hours and exhibits antimycobacterial activity with a MIC99 of 5.0 µM against Mycobacterium tuberculosis H37Rv..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis. |
| Synonyms | 4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide |
| Molecular Weight | 326.33 |
| Formula | C15H10N4O3S |
| Cas No. | 476319-66-1 |
| Smiles | N(C(=O)C1=CC=C(N(=O)=O)C=C1)C2=NC(=CS2)C3=CC=CC=N3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.56 mg/mL (17.04 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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