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Cytisinicline

Name: Cytisinicline
Brand: TargetMol
SKU: T0479
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0479Cas No. 485-35-8

Alias Sophorine, Cytisine, Baptitoxine, Baphitoxine

Cytisinicline (Sophorine), an alkaloid, is found naturally in several plants.

Cytisinicline

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Purity: 99.41%

Catalog No. T0479Alias Sophorine, Cytisine, Baptitoxine, BaphitoxineCas No. 485-35-8

Cytisinicline (Sophorine), an alkaloid, is found naturally in several plants.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$29	In Stock	In Stock
25 mg	$40	In Stock	In Stock
50 mg	$56	In Stock	In Stock
100 mg	$79	In Stock	In Stock
500 mg	$159	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.41%

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Cytisinicline AI Summary

Cytisinicline exhibits potent bioactivity related to nicotinic acetylcholine receptors (nAChRs) across various subtypes and species. It shows high affinity for the alpha4beta2 nAChR subtype, with Ki values as low as 0.28 nM in human and 0.4 nM in rat brain tissues. The compound also demonstrates binding affinities for other nAChR subtypes, including alpha7 (Ki values from 0.9 nM to 5820.0 nM) and alpha3beta4 (Ki values from 18.0 nM to 203.0 nM). Additionally, Cytisinicline is effective in displacing radioligands such as [3H]epibatidine and [3H]cytisine, indicating its strong competitive inhibition capability. The compound also shows efficacy in bioassays involving human and rat brain tissues, affecting neurotransmission by inhibiting or activating nAChR subtypes with various EC50 and IC50 values. Furthermore, it demonstrates a potential role in modulating dopaminergic release and acetylcholine-induced changes in membrane potential in neural cells. Cytisinicline has been noted for partially agonistic activity at specific receptor subtypes and exhibits selectivity towards the alpha4beta2 subtype, suggesting potential therapeutic applications in nicotinic receptor-related disorders. Moreover, the compound has shown antiviral activity against SARS-CoV-2, although with moderate to low potency..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cytisinicline (Sophorine), an alkaloid, is found naturally in several plants.
Synonyms	Sophorine, Cytisine, Baptitoxine, Baphitoxine

Chemical Properties

Molecular Weight	190.24
Formula	C₁₁H₁₄N₂O
Cas No.	485-35-8
Smiles	[H][C@@]12CNC[C@@]([H])(C1)c1cccc(=O)n1C2
Relative Density.	1.24 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 36 mg/mL (189.23 mM), Sonication is recommended.

H2O: 125 mg/mL (657.06 mM), Sonication is recommended.

DMSO: 84 mg/mL (441.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (17.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	5.2565 mL	26.2826 mL	52.5652 mL	262.8259 mL
5 mM	1.0513 mL	5.2565 mL	10.5130 mL	52.5652 mL
10 mM	0.5257 mL	2.6283 mL	5.2565 mL	26.2826 mL
20 mM	0.2628 mL	1.3141 mL	2.6283 mL	13.1413 mL
50 mM	0.1051 mL	0.5257 mL	1.0513 mL	5.2565 mL
100 mM	0.0526 mL	0.2628 mL	0.5257 mL	2.6283 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc