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TRPM8 antagonist 2

Name: TRPM8 antagonist 2
Brand: TargetMol
SKU: T5698
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5698Cas No. 259674-19-6

TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.

TRPM8 antagonist 2

🥰Excellent

Purity: 98.1%

Catalog No. T5698Cas No. 259674-19-6

TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$64	In Stock
10 mg	$106	In Stock
25 mg	$179	In Stock
50 mg	$289	In Stock
100 mg	$463	In Stock
200 mg	$666	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock

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Purity:98.1%

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Product Introduction

Bioactivity

Description	TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
Targets&IC50	TRPM8:0.2 nM
In vitro	TRPM8 antagonist 2 (Compound 14) is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM, used in neuropathic pain research. It effectively inhibits menthol-induced increases in intracellular Ca2+ levels in Ca2+ fluorimetric assays in HEK293 cells expressing the rat TRPM8 isoform (IC50, 40 nM).
In vivo	TRPM8 antagonist 2, administered subcutaneously at doses of 1, 10, and 30 mg/kg, demonstrates significant, dose-dependent antinociceptive effects and reduces wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at the 30 mg/kg dosage. Additionally, at lower doses of 0.1 and 1 μg, it effectively mitigates Oxaliplatin (OXP)-induced cold allodynia in mice.

Chemical Properties

Molecular Weight	398.5
Formula	C₂₆H₂₆N₂O₂
Cas No.	259674-19-6
Smiles	COC(=O)[C@H](Cc1c[nH]c2ccccc12)N(Cc1ccccc1)Cc1ccccc1
Relative Density.	1.195 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (401.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5094 mL	12.5471 mL	25.0941 mL	125.4705 mL
5 mM	0.5019 mL	2.5094 mL	5.0188 mL	25.0941 mL
10 mM	0.2509 mL	1.2547 mL	2.5094 mL	12.5471 mL
20 mM	0.1255 mL	0.6274 mL	1.2547 mL	6.2735 mL
50 mM	0.0502 mL	0.2509 mL	0.5019 mL	2.5094 mL
100 mM	0.0251 mL	0.1255 mL	0.2509 mL	1.2547 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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