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Isoorientin

Name: Isoorientin
Brand: TargetMol
SKU: T6S0722
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S0722Cas No. 4261-42-1

Alias Luteolin-6-C-glucoside, Homoorientin

Isoorientin (Homoorientin) has antioxidant activity.

Isoorientin

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Purity: 99.93%

Catalog No. T6S0722Alias Luteolin-6-C-glucoside, HomoorientinCas No. 4261-42-1

Isoorientin (Homoorientin) has antioxidant activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
5 mg	$76	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$247	In Stock	In Stock
50 mg	$396	-	In Stock
100 mg	$579	-	In Stock
500 mg	$1,220	-	In Stock
1 mL x 10 mM (in DMSO)	$84	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White to Yellow

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COA LCMS

Product Introduction

Isoorientin AI Summary

Isoorientin exhibits a broad spectrum of bioactivities across various biological systems. It shows significant antibacterial activity against Streptococcus faecalis, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 25.0 µg/mL. Its antifungal efficacy includes activity against Cryptococcus neoformans (MIC 25.0 µg/mL), Trichophyton mentagrophytes (MIC 12.5 µg/mL), and Aspergillus fumigatus (MIC 50.0 µg/mL). However, it is less effective against Pseudomonas aeruginosa and Candida species, with MIC values exceeding 50.0 µg/mL. In enzymatic assays, Isoorientin displays inhibitory effects on cow milk xanthine oxidase at 50 µg/mL concentration (25.2% inhibition) and has a notable impact on platelet aggregation, significantly inhibiting thrombin, arachidonic acid, collagen, and platelet activating factor-induced aggregation in rabbit plasma at 300 µM. It also inhibits muscle contractions in Wistar rat thoracic aorta under high potassium conditions. The compound demonstrates antioxidant properties by scavenging ABTS and peroxy radicals (1.56 trolox equivalent in ABTS assay and 66.5 trolox equivalent in the ORAC assay) and exhibits antiproliferative activity against human HepG2 cells with significant effects observed at both 24 and 48-hour intervals. Isoorientin shows low cytotoxicity in human Huh7.5.1 cells (CC50 > 50,000 nM) and has moderate inhibition of electric eel acetylcholinesterase (23.87% at 2 mg/mL). It also impedes aldose reductase with an IC50 of 1910 nM and displays mixed effects in viral assays, with a limited inhibition of Influenza A virus polymerase acidic subunit binding (IC50 > 50,000 nM). In addition, Isoorientin inhibits several enzymes and proteins involved in cellular processes, including non-competitive inhibition of GSK3-beta, with broader implications in neuroprotection and signal transduction. It notably hinders Bacillus stearothermophilus alpha-glucosidase (IC50 1525700 nM) and various human and viral enzymes, underscoring its multifunctional biological activity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isoorientin (Homoorientin) has antioxidant activity.
Targets&IC50	COX-2:39 μM.
Synonyms	Luteolin-6-C-glucoside, Homoorientin

Chemical Properties

Molecular Weight	448.38
Formula	C₂₁H₂₀O₁₁
Cas No.	4261-42-1
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1
Relative Density.	1.759g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (278.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2303 mL	11.1513 mL	22.3025 mL	111.5126 mL
5 mM	0.4461 mL	2.2303 mL	4.4605 mL	22.3025 mL
10 mM	0.2230 mL	1.1151 mL	2.2303 mL	11.1513 mL
20 mM	0.1115 mL	0.5576 mL	1.1151 mL	5.5756 mL
50 mM	0.0446 mL	0.2230 mL	0.4461 mL	2.2303 mL
100 mM	0.0223 mL	0.1115 mL	0.2230 mL	1.1151 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc